Cells and aggregates at surfaces.
Cells and aggregates at surfaces.
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表面的细胞和聚集体。
DOI：
10.1111/j.1749-6632.1987.tb33066.x
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发表时间：
1987
影响因子：
5.2
通讯作者：
Fuster,V
中科院分区：
文献类型：
--
作者：
Turitto,VT;Weiss,HJ;Baumgartner,HR;Badimon,L;Fuster,V
在过去的十年中，在控制细胞与表面相互作用的物理和化学事件方面已经取得了相当大的进展。细胞物质与异质表面的附着以及随后细胞沉积物的生长是一种基本的生物现象，它是生物体中许多稳态功能的基础，此外还形成了从肿瘤细胞转移和血栓形成到动脉粥样硬化过程演变的病理过程的基础。在本文中，我们将主要关注血小板和受损血管材料的相互作用，作为血栓形成中重要的细胞事件的模型。血小板与血管或假体表面相互作用的第一个显微镜可见步骤是细胞粘附到表面，在适当的条件下，随后迅速发生血小板彼此的内聚。我们将主要考虑后一个事件，即血小板聚集体在表面上的生长和稳定，并理解聚集体生长本质上取决于细胞与基质的先前和持续粘附。细胞，特别是血小板，直接粘附到表面是一个自十年前纽约科学院会议就该主题进行以来，从理论和实验角度来看都取得了相当大进展的事件。然而，本卷的几个章节都介绍了这一事件，并且最近对血小板粘附主题进行了回顾。*
During the past 10 years, considerable progress has been achieved concerning the physical and chemical events that govern the interaction of cells with surfaces. The attachment of cellular material to a foreign surface and the subsequent growth of the cellular deposit is a fundamental biological phenomenon that underlies numerous homeostatic functions in living organisms and in addition forms the bases for pathological processes ranging from metastases of tumor cells and thrombosis to the evolution of the atherosclerotic process. In this article we shall be concerned primarily with the interaction of blood platelets and damaged vascular material as a model for the cellular events important in thrombosis. The first microscopically visible step in the interaction of platelets with a vascular or prosthetic surface is adhesion of the cell to the surface, which under the appropriate conditions is rapidly followed by the subsequent cohesion of platelets to each other. We will consider primarily the latter event, the growth and stabilization of platelet aggregates on surfaces, with the understanding that aggregate growth is essentially dependent on prior and continuing adhesion of cells to the substrate. The adhesion of cells, especially platelets, directly to the surface is an event that has been considerably advanced from both a theoretical and experimental viewpoint since the proceedings of the previous New York Academy of Sciences conference on this subject ten years ago’; however, this event is covered in several chapters in the present volume and the subject of platelet adhesion has been recently reviewed.*