Anemia of Acute Infection in Hospitalized Children- No Evidence of Hemolysis
Anemia of Acute Infection in Hospitalized Children- No Evidence of Hemolysis
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DOI：
10.1097/mph.0b013e3181b79696
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发表时间：
2009-10-01
影响因子：
1.2
通讯作者：
Rief, Shimon
中科院分区：
文献类型：
--
作者：
Ballin, Ami;Lotan, Amir;Rief, Shimon
本研究的目的是检验溶血过程在儿童急性感染性贫血中发挥作用的假设。该研究由血液或尿液培养阳性的发热儿科患者组成。全血细胞计数的措施进行了比较，住院和住院前或住院后的价值。入院接受择期手术的儿童作为对照组。对部分患者的溶血血液参数进行了研究。在研究的70例患者中，49例（70%）被诊断为肾盂肾炎，21例（30%）有菌血症。入院时平均（+/- SD）血红蛋白（Hgb）为10.9 +/- 1.27 g/L，对照组为12.1 +/- 1.03 g/L，P < 0.0001。以正常血红蛋白值为标准，42例（60%）被确定为贫血。与入院时相比，入院前或入院后Hgb和Hct明显升高，而WBC明显降低。所有溶血参数，即网织红细胞、胆红素、乳酸脱氢酶（LDH）和结合珠蛋白均正常。菌血症和肾盂肾炎伴有血红蛋白水平显著下降。在这些患者中没有溶血性贫血的证据。
The objective of the study is to examine the assumption that a process of hemolysis plays a role in anemia of acute infection in children. The study was comprised of febrile pediatric patients, who had a positive blood or urine culture. Complete blood count measures were compared between hospitalization and prehospitalization or posthospitalization values. Children admitted to the hospital for elective surgical procedures served as controls. Blood parameters of hemolysis were investigated in some of the patients. Of the 70 patients studied, 49 (70%) were diagnosed with pyelonephritis and 21 (30%) had bacteremia. Mean (+/- SD) hemoglobin (Hgb) on hospital admission was 10.9 +/- 1.27 g/L as compared with 12.1 +/- 1.03 g/L of the controls, P < 0.0001. Compared with normal-for-age Hgb values as a standard, 42 (60%) cases were identified as anemic. Compared with hospitalization values, Hgb and hematocrit (Hct) were significantly higher in prehospitalization or posthospitalization, whereas WBC values were significantly lower. All parameters of hemolysis, namely reticulocytes, bilirubin, lactate dehydrogenase (LDH), and haptoglobin, were normal. Bacteremia and pyelonephritis are accompanied by a significant drop in Hgb level. There is no evidence of hemolytic anemia in these patients.