Metabolic engineering of sugar catabolism in lactic acid bacteria
Metabolic engineering of sugar catabolism in lactic acid bacteria
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DOI：
10.1007/bf00395934
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发表时间：
1996-10-01
影响因子：
2.6
通讯作者：
deVos, WM
中科院分区：
文献类型：
--
作者：
deVos, WM
乳酸菌的特征是一种相对简单的糖发酵途径，根据定义，该途径会导致乳酸的形成。对传统途径的广泛了解以及关于这些途径和新途径的遗传信息的积累，使得可以通过生理途径、遗传方法或两者的组合来改变乳酸菌的代谢过程。本综述将讨论乳酸菌代谢工程用于生产重要化合物的过去和现在的例子和未来的可能性，包括乳酸和其他酸、风味化合物和胞外多糖。
Lactic acid bacteria are characterized by a relatively simple sugar fermentation pathway that, by definition, results in the formation of lactic acid. The extensive knowledge of traditional pathways and the accumulating genetic information on these and novel ones, allows for the rerouting of metabolic processes in lactic acid bacteria by physiological approaches, genetic methods, or a combination of these two. This review will discuss past and present examples and future possibilities of metabolic engineering of lactic acid bacteria for the production of important compounds, including lactic and other acids, flavor compounds, and exopolysaccharides.