Utility of the sleep stage sequence preceding sleep onset REM periods for the diagnosis of narcolepsy: a study in a Japanese cohort.
Utility of the sleep stage sequence preceding sleep onset REM periods for the diagnosis of narcolepsy: a study in a Japanese cohort.
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睡眠开始快速眼动期之前的睡眠阶段序列在诊断发作性睡病中的效用：一项日本队列研究。
DOI：
10.1016/j.sleep.2019.04.008
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发表时间：
2020
期刊：
影响因子：
4.8
通讯作者：
Kitajima T.
中科院分区：
文献类型：
--
作者：
Kawai R;Watanabe A;Fujita S;Hirose M;Esaki Y;Arakawa C;Iwata N;Kitajima T.
BackgroundThe minimum narcolepsy criteria “mean sleep latency (MSL) ≤8 min and ≥2 sleep onset rapid eye movement (REM) periods (SOREMPs) on polysomnography (PSG) and the multiple sleep latency test (MSLT),” according to The International Classification of Sleep Disorders, Third Edition (ICSD-3), are not specific to narcolepsy. Recently, the characteristic sleep stage sequences preceding SOREMPs in narcolepsy have received attention, but their diagnostic utility remains unclear.MethodsWe retrospectively reviewed PSG/MSLT records and chart data for 102 Japanese patients with hypersomnia and at least one SOREMP. We examined the sporadic rates of two sleep stage sequences preceding the SOREMPs—wakefulness or stage 1 to REM (W/S1→R) and stage 2 to REM (S2→R)—comparing these between patient groups with narcolepsy type 1 (N = 28), narcolepsy type 2 (N = 19), and other hypersomnia (N = 55). We also examined the utility of three simple indices using the occurrence of W/S1→R SOREMPs for distinguishing between narcolepsy and other hypersomnia in patients who satisfied the minimum narcolepsy criteria.ResultsW/S1→R SOREMPs were significantly more frequent in narcolepsy than in other hypersomnia, and this tendency was also observed even in the patients who satisfied the minimum narcolepsy criteria. The three indices had moderate sensitivities and specificities for distinguishing between narcolepsy and other hypersomnia in patients satisfying the minimum narcolepsy criteria.ConclusionsThe W/S1→R pattern was observed significantly more frequently in narcolepsy than in other hypersomnia, suggesting it may help with differentiating narcolepsy from other hypersomnia in patients demonstrating the narcolepsy criteria, although its ability to do so may be modest.
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影响因子：
29
作者：
Andlauer, Olivier;Moore, Hyatt;Jouhier, Laura;Drake, Christopher;Peppard, Paul E.;Han, Fang;Hong, Seung-Chul;Poli, Francesca;Plazzi, Giuseppe;O'Hara, Ruth;Haffen, Emmanuel;Roth, Thomas;Young, Terry;Mignot, Emmanuel
通讯作者：
Mignot, Emmanuel
DOI：
10.5664/jcsm.4940
发表时间：
2015-08
期刊：
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
影响因子：
--
作者：
Yaping Liu;Jihui Zhang;V. Lam;C. Ho;Junying Zhou;Shirley Xin Li;S. Lam;M. Yu;Xiangdong Tang;Y. Wing
通讯作者：
Yaping Liu;Jihui Zhang;V. Lam;C. Ho;Junying Zhou;Shirley Xin Li;S. Lam;M. Yu;Xiangdong Tang;Y. Wing
发作性睡病：遗传倾向和神经药理学机制。
影响因子：
10.5
作者：
S. Nishino;M. Okura;E. Mignot
通讯作者：
E. Mignot
优化 MSLT 在猝倒发作性睡病中的特异性
影响因子：
5.6
作者：
Tobias Murer;L. Imbach;M. Hackius;R. Taddei;E. Werth;R. Poryazova;Yury V. Gavrilov;Sophie Winkler;D. Waldvogel;C. Baumann;P. Valko
通讯作者：
P. Valko
非裔美国人的发作性睡病。
影响因子：
5.6
作者：
Kawai,Makoto;O'Hara,Ruth;Einen,Mali;Lin,Ling;Mignot,Emmanuel
通讯作者：
Mignot,Emmanuel