Emerging Trends in Polymerization-Induced Self-Assembly
Emerging Trends in Polymerization-Induced Self-Assembly
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DOI：
10.1021/acsmacrolett.9b00464
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发表时间：
2019-08-01
影响因子：
7.015
通讯作者：
Armes, Steven P.
中科院分区：
文献类型：
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作者：
Penfold, Nicholas J. W.;Yeow, Jonathan;Armes, Steven P.
本文综述了聚合诱导自组装（比萨）技术在合理合成不同形貌嵌段共聚物纳米粒子方面的最新进展。大部分的比萨文献是基于热引发的可逆加成-断裂链转移（RAFT）聚合。在此，我们特别注意替代比萨协议，它允许制备纳米粒子与改进的控制共聚物的形态和功能。例如，基于可见光、氧化还原化学或酶的引发使得能够将敏感单体和易碎生物分子掺入嵌段共聚物纳米颗粒中。此外，比萨合成和所得纳米颗粒的后官能化（例如，交联）可以通过使用各种外部刺激而连续进行而无需中间纯化。最后，比萨配方已通过高通量聚合进行了优化，最近在流动反应器内进行了评估，以便于放大合成。
In this Perspective, we summarize recent progress in polymerization-induced self-assembly (PISA) for the rational synthesis of block copolymer nanoparticles with various morphologies. Much of the PISA literature has been based on thermally initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. Herein, we pay particular attention to alternative PISA protocols, which allow the preparation of nanoparticles with improved control over copolymer morphology and functionality. For example, initiation based on visible light, redox chemistry, or enzymes enables the incorporation of sensitive monomers and fragile biomolecules into block copolymer nanoparticles. Furthermore, PISA syntheses and postfunctionalization of the resulting nanoparticles (e.g., cross-linking) can be conducted sequentially without intermediate purification by using various external stimuli. Finally, PISA formulations have been optimized via high-throughput polymerization and recently evaluated within flow reactors for facile scale-up syntheses.