Presence of prostate cancer metastasis correlates with lower lymph node reactivity
Presence of prostate cancer metastasis correlates with lower lymph node reactivity
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DOI：
10.1002/pros.20466
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发表时间：
2006-12-01
期刊：
影响因子：
2.8
通讯作者：
Saad, Fred
中科院分区：
文献类型：
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作者：
Gannon, Philippe Olivier;Fahmy, Mona Alam;Saad, Fred
背景资料。几篇报道表明，肿瘤细胞的扩散和肿瘤进展与免疫抑制环境的形成有关。方法在这篇报道中，我们通过免疫组织化学和组织学分析，比较了25例肿瘤累及盆腔淋巴结的转移和未转移的盆腔淋巴结(LN)和26例无转移的对照患者的非转移性盆腔淋巴结，研究了前列腺癌的免疫学效应。结果发现，CD20+B淋巴细胞(P=0.031)、CD38+活化的淋巴细胞(P=0.038)和CD68+巨噬细胞(P<；与对照组相比，转移性淋巴结的滤泡增生(P=0.014)、窦性增生(P<；0.001)和纤维化(P=0.028)明显减少。最后，我们观察到转移性淋巴结明显小于对照组(P=0.005)。结论：我们的结果提示前列腺癌LN转移伴随着LN体积变小和LN反应性降低，提示存在免疫抑制的微环境。
BACKGROUND. Several reports suggest that the dissemination of neoplastic cells and cancer progression are associated with the generation of an immunosuppressive environment.METHODS. In this report, we investigated immunological effects of prostate cancer by comparing metastastic and non-metastatic pelvic lymph nodes (LNs) from 25 patients with carcinomatous involvement of LNs to the non-metastatic LNs from 26 control patients with no metastatic involvement by immunohistochemistry and histological analyses.RESULTS. Our results showed a decreased abundance of CD20+ B lymphocytes (P = 0.031), CD38+ activated lymphocytes (P = 0.038), and CD68+ macrophages (P < 0.001), and less evidence of follicular hyperplasia (P = 0.014), sinus hyperplasia (P < 0.001), and fibrosis (P = 0.028) in metastatic LNs comparatively to control LN's. Finally, we observed that metastatic LNs were significantly smaller than control LNs (P = 0.005).CONCLUSIONS. Our results suggest that the development of prostate cancer LN metastasis is accompanied with smaller LN size and decreased LN reactivity suggesting the development of an immununosuppressive microenvironment.