Antimicrobial and Antifouling Polymeric Agents for Surface Functionalization of Medical Implants
Antimicrobial and Antifouling Polymeric Agents for Surface Functionalization of Medical Implants
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用于医疗植入物表面功能化的抗菌和防污聚合物制剂
DOI：
10.1021/acs.biomac.8b00399
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发表时间：
2018
影响因子：
6.2
通讯作者：
Xu Fu-Jian
中科院分区：
文献类型：
--
作者：
Zeng Qiang;Zhu Yiwen;Yu Bingran;Sun Yujie;Ding Xiaokang;Xu Chen;Wu Yu-Wei;Tang Zhihui;Xu Fu-Jian
由于关节置换和牙科修复等外科手术的数量不断增加，因此迫切需要防治植入物相关感染。用聚合物抗微生物剂和消毒剂对可植入医疗器械进行表面功能化是防止细菌污染和相关感染的有效策略。本论文以庆大霉素和乙二醇为原料，通过开环反应合成了具有抗菌活性的支链聚合物（GPEG和GEG）。由于它们富含伯胺基团，它们可以容易地涂覆在聚多巴胺改性的植入物（如钛）表面上。Ti-GPEG和Ti-GEG表面涂层对金黄色葡萄球菌和大肠杆菌均有较好的体外抗菌效果，而Ti-GPEG具有较好的亲水性。此外，还研究了S.结果表明，植入的Ti-GPEG具有良好的体内抗菌性和生物相容性。该研究为植入式医疗器械的表面功能化提供了一种有前途的策略，以防止植入相关感染。
Combating implant-associated infections is an urgent demand due to the increasing numbers in surgical operations such as joint replacements and dental implantations. Surface functionalization of implantable medical devices with polymeric antimicrobial and antifouling agents is an efficient strategy to prevent bacterial fouling and associated infections. In this work, antimicrobial and antifouling branched polymeric agents (GPEG and GEG) were synthesized via ring-opening reaction involving gentamicin and ethylene glycol species. Due to their rich primary amine groups, they can be readily coated on the polydopamine-modified implant (such as titanium) surfaces. The resultant surface coatings of Ti-GPEG and Ti-GEG produce excellentin vitroantibacterial efficacy toward bothStaphylococcus aureusandEscherichia coli, while Ti-GPEG exhibit better antifouling ability. Moreover, the infection model withS. aureusshows that implanted Ti-GPEG possessed excellent antibacterial and antifouling abilityin vivo. This study would provide a promising strategy for the surface functionalization of implantable medical devices to prevent implant-associated infections.