Genetic and Environmental Influences on Cardiovascular Disease Risk Factors: A Study of Chinese Twin Children and Adolescents
Genetic and Environmental Influences on Cardiovascular Disease Risk Factors: A Study of Chinese Twin Children and Adolescents
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DOI：
10.1017/thg.2014.5
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发表时间：
2014-04-01
影响因子：
0.9
通讯作者：
Silventoinen, Karri
中科院分区：
文献类型：
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作者：
Ji, Fuling;Ning, Feng;Silventoinen, Karri
我们评估了遗传和环境因素对代谢性心血管危险因素的影响及其相互关联。对来自中国青岛双胞胎登记中心的508对8-17岁的双胞胎进行了8项代谢因子（体重指数、腰围、腰臀比、收缩压、舒张压、血清总胆固醇、血清甘油三酯和血清尿酸）测量。利用线性结构方程模型估计了这些性状的遗传力以及它们之间的遗传相关性和环境相关性。在男孩中，身体质量指数和尿酸表现出一贯的高遗传力（0.49-0.81），而在儿童（8-12岁）和青少年（13-17岁）中，除总胆固醇外，其他性状表现出中等至高的常见环境变异（0.37-0.73）。在女孩中，6个代谢性状在儿童中具有中至高遗传力（0.39 ~ 0.75），而在青少年中只有2个性状具有高遗传力，其他性状大多具有中至大的共同环境方差。男孩和女孩的遗传相关性都很强（体重指数和舒张压之间的r(g) = 0.64-0.99）；体重指数与腰围之间的R (g) = 0.71-1.00)，但青春期女孩的R (g) = 0.51(体重指数与腰臀比之间的R (g) = 0.51；体重指数与尿酸之间的R (g) = 0.55；体重指数与收缩压之间的R (g) = 0.61)。遗传因素对大多数代谢性状的影响从童年到青春期逐渐减弱。共同的遗传因素和特定的环境因素影响着大多数代谢性状之间的相互关联。
We evaluated the genetic and environmental contributions to metabolic cardiovascular risk factors and their mutual associations. Eight metabolic factors (body mass index, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, total serum cholesterol, serum triglycerides, and serum uric acid) were measured in 508 twin pairs aged 8-17 years from the Qingdao Twin Registry, China. Linear structural equation models were used to estimate the heritability of these traits, as well as the genetic and environmental correlations between them. Among boys, body mass index and uric acid showed consistently high heritability (0.49-0.81), whereas other traits showed moderate to high common environmental variance (0.37-0.73) in children (8-12 years) and adolescents (13-17 years) except total cholesterol. For girls, moderate to high heritability (0.39-0.75) were obtained for six metabolic traits in children, while only two traits showed high heritability and others mostly medium to large common environmental variance in adolescents. Genetic correlations between the traits were strong in both boys and girls in children (r(g) = 0.64-0.99 between body mass index and diastolic blood pressure; r(g) = 0.71-1.00 between body mass index and waist circumference), but decreased for adolescent girls (r(g) = 0.51 between body mass index and waist-to-hip ratio; r(g) = 0.55 between body mass index and uric acid; r(g) = 0.61 between body mass index and systolic blood pressure). The effect of genetic factors on most metabolic traits decreased from childhood to adolescence. Both common genetic and specific environmental factors influence the mutual associations among most of the metabolic traits.