Ghrelin increases anxiety-like behavior and memory retention in rats
Ghrelin increases anxiety-like behavior and memory retention in rats
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DOI：
10.1016/s0006-291x(02)02740-7
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发表时间：
2002-12-20
影响因子：
3.1
通讯作者：
de Barioglio, SR
中科院分区：
文献类型：
--
作者：
Carlini, VP;Monzón, ME;de Barioglio, SR
生长素释放肽是一种存在于下丘脑和胃中的肽，可刺激食物摄入，其循环浓度受营养状态影响。人们对生长素释放肽的其他主要行为影响知之甚少，因此，我们研究了生长素释放肽对焦虑和记忆保留的影响。该肽被注射到大鼠脑室内，我们进行了旷场、十字迷宫和逐步下降测试（抑制性回避）。施用生长素释放肽增加了开放区域的冻结，并减少了进入开放空间的次数以及在十字迷宫中张开手臂上花费的时间，这表明存在致焦虑作用。此外，肽以剂量依赖性方式增加了降压测试中的潜伏时间。还观察到食物摄入量快速且长期增加。我们的结果表明，生长素释放肽可诱导大鼠产生焦虑。此外，我们首次证明生长素释放肽可以增加记忆保留，这表明该肽可能影响海马体的过程。 (C) 2002 年爱思唯尔科学（美国）。版权所有。
Ghrelin is a peptide found in the hypothalamus and stomach that stimulates food intake and whose circulating concentrations are affected by nutritional state. Very little is known about other central behavioral effects of ghrelin, and thus, we investigated the effects of ghrelin on anxiety and memory retention. The peptide was injected intracerebroventricularly in rats and we performed open-field, plus-maze, and step-down tests (inhibitory avoidance). The administration of ghrelin increased freezing in the open field and decreased the number of entries into the open spaces and the time spent on the open arms in the plus-maze, indicating an anxiogenic effect. Moreover, the peptide increased in a dose-dependent manner the latency time in the step-down test. A rapid and prolonged increase in food intake was also observed. Our results indicate that ghrelin induces anxiogenesis in rats. Moreover, we show for the first time that ghrelin increases memory retention, suggesting that the peptide may influence processes in the hippocampus. (C) 2002 Elsevier Science (USA). All rights reserved.