Modular protein domains: an engineering approach toward functional biomaterials.
Modular protein domains: an engineering approach toward functional biomaterials.
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DOI：
10.1016/j.copbio.2016.02.011
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发表时间：
2016-08
影响因子：
7.7
通讯作者：
Liu JC
中科院分区：
文献类型：
--
作者：
Lin CY;Liu JC
蛋白质结构域和肽序列是赋予工程生物材料特定功能的有力工具。具有广泛功能的蛋白质序列，包括结构，生物活性，蛋白质-蛋白质相互作用和刺激响应性，已被确定，分子生物学的进展继续查明新的序列。蛋白质结构域可以组合以制备具有多种功能的重组蛋白。蛋白质翻译机器的高保真度导致对重组蛋白质序列的精确控制以及基于蛋白质的材料的所得性质。在这篇综述中，我们讨论了蛋白质结构域和肽序列的背景下，功能蛋白质为基础的材料，复合材料，及其生物学应用。
Protein domains and peptide sequences are a powerful tool for conferring specific functions to engineered biomaterials. Protein sequences with a wide variety of functionalities, including structure, bioactivity, protein-protein interactions, and stimuli responsiveness, have been identified, and advances in molecular biology continue to pinpoint new sequences. Protein domains can be combined to make recombinant proteins with multiple functionalities. The high fidelity of the protein translation machinery results in exquisite control over the sequence of recombinant proteins and the resulting properties of protein-based materials. In this review, we discuss protein domains and peptide sequences in the context of functional protein-based materials, composite materials, and their biological applications.