Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia.
Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia.
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DOI：
10.1176/ajp.147.11.1457
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
P. Barta;G. Pearlson;R. Powers;S. S. Richards-S.;L. Tune
中科院分区：
文献类型：
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作者：
P. Barta;G. Pearlson;R. Powers;S. S. Richards-S.;L. Tune
最近精神分裂症的神经病理学研究报告内侧颞叶结构体积较小。这些发现得到了初步磁共振成像(MRI)研究的证实。直接刺激颞上回区域的外侧颞叶结构会引起幻觉。作者对年轻精神分裂症患者的核磁共振研究显示，颞上回(听觉关联区)和左侧杏仁核的体积较小。较小的左侧颞上回和左侧杏仁核并不能解释整个大脑或颞叶较小的原因。左额叶上回的萎缩与幻听的严重程度有强烈和选择性的相关性。
Recent neuropathologic investigations in schizophrenia report smaller volume of medial temporal lobe structures. These findings are confirmed by preliminary magnetic resonance imaging (MRI) studies. Direct stimulation of lateral temporal lobe structures in the region of the superior temporal gyrus provokes hallucinations. The authors' MRI study of young schizophrenic patients demonstrates smaller volume of the superior temporal gyrus (an auditory association area) and of the left amygdala. Smaller size of the left superior temporal gyrus and left amygdala is not accounted for by smaller size of the overall brain or temporal lobe. Shrinkage of the left superior temporal gyrus is strongly and selectively correlated with severity of auditory hallucinations.