ACETYLSALICYLIC-ACID, BLEEDING-TIME AND AGE
ACETYLSALICYLIC-ACID, BLEEDING-TIME AND AGE
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DOI：
10.1016/0049-3848(80)90007-9
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发表时间：
1980-01-01
影响因子：
7.5
通讯作者：
STOFFERSEN, E
中科院分区：
文献类型：
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作者：
JORGENSEN, KA;DYERBERG, J;STOFFERSEN, E
在不同年龄的50名男性和20名女性中，测定了摄入1（BT 1）、3.5（BT3.5）和25（BT 25）mg乙酰水杨酸（阿萨）/kg之前（BT 0）和之后的出血时间。男性BT 0福尔斯随年龄增长而下降，可能是由于PGI 2/TXA 2比值降低。出血时间的改变可以通过服用阿萨来消除。指数Ia =（BT 25-BT 0）/BT 25在男性和女性中均随年龄增加而增加。虽然所有年龄组在给予小剂量阿司匹林后出血时间增加，但只有在较年轻的年龄组中，当剂量增加到25 mg/kg时，出血时间才显著下降。
Bleeding time was determined before (BT0) and after ingestion of 1 (BT1), 3.5 (BT3.5) and 25 (BT25) mg acetylsalicylic acid (ASA)/kg in 50 men and 20 women of varying age. BT0 falls with age in men, perhaps due to a reduction in PGI2/TXA2 ratio. The changes in bleeding time could be abolished by ASA ingestion. The index Ia = (BT25-BT0)/BT25 increased with age in both men and women. While all age groups increased bleeding time upon administration of a small dose of aspirin, only in the younger age groups did the bleeding time thereafter fall significantly, when the dose was increased to 25 mg/kg.