IDENTIFICATION OF HUMAN BRAIN-REGIONS UNDERLYING RESPONSES TO RESISTIVE INSPIRATORY LOADING WITH FUNCTIONAL MAGNETIC-RESONANCE-IMAGING
IDENTIFICATION OF HUMAN BRAIN-REGIONS UNDERLYING RESPONSES TO RESISTIVE INSPIRATORY LOADING WITH FUNCTIONAL MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1073/pnas.92.14.6607
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发表时间：
1995-07-03
影响因子：
11.1
通讯作者：
HARPER, RM
中科院分区：
文献类型：
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作者：
GOZAL, D;OMIDVAR, O;HARPER, RM
在一些肺部疾病中，对吸气负荷增加的代偿性呼吸反应对于适当的呼吸调节是必不可少的；然而，调节这种反应的人脑部位尚不清楚。用功能性磁共振成像(FMRI)技术(1.5特斯拉磁共振；重复时间72毫秒；回声时间45毫秒；翻转角30度；视野26厘米；层厚5毫米；激发次数1次；数字图像减影和感兴趣区分析显示，在腹侧和背侧笔、脚间核、基底前脑、壳核和小脑区的离散区域，数字图像减影和感兴趣区的信号强度显著增加，当负荷退出时，某些区域显示出快速的瞬时信号，而在其他区域，出现了较慢的功能磁共振信号衰减，持续负荷引起激活区域的功能磁共振信号缓慢下降，而第二次施加相同的负荷导致与初始信号响应相比较小的信号增加(P<；0.001)。适度的吸气负荷与大脑离散区域的持续激活有关；在动物模型中，这些区域中的某些区域参与了负荷呼吸的调节，我们推测fMRI信号的时间变化可能表明呼吸后放电和/或习惯化现象。
Compensatory ventilatory responses to increased inspiratory loading are essential for adequate breathing regulation in a number of pulmonary diseases; however, the human brain sites mediating such responses are unknown. Midsagittal and axial images were acquired in II healthy volunteers during unloaded and loaded (30 cmH(2)O; 1 cmH(2)O = 98 Pa) inspiratory breathing, by using functional magnetic resonance imaging (fMRI) strategies (1.5-tesla MR; repetition time, 72 msec; echo time, 45 msec; flip angle, 30 degrees; field of view, 26 cm; slice thickness, 5 mm; number of excitations, 1; matrix, 128 x 256), Digital image subtractions and region of interest analyses revealed significantly increased fMRI signal intensity in discrete areas of the ventral and dorsal pens, interpeduncular nucleus, basal forebrain, putamen, and cerebellar regions, Upon load withdrawal, certain regions displayed a rapid fMRI signal off-transient, while in others, a slower fMRI signal decay emerged, Sustained loading elicited slow decreases in fMRI signal across activated regions, while second application of an identical load resulted in smaller signal increases compared to initial signal responses (P < 0.001). A moderate inspiratory load is associated with consistent regional activation of discrete brain locations; certain of these regions have been implicated in mediation of loaded breathing in animal models, We speculate that temporal changes in fMRI signal may indicate respiratory after-discharge and/or habituation phenomena.