Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor.
Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor.
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DOI：
10.1126/science.6093254
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发表时间：
1984-11
期刊：
影响因子：
56.9
通讯作者：
R. Tucker;G. Shipley;H. Moses;R. W. Holley
中科院分区：
文献类型：
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作者：
R. Tucker;G. Shipley;H. Moses;R. W. Holley
来自BSC-1细胞的纯化生长抑制剂和来自人血小板的β型转化生长因子显示出具有几乎相同的生物活性，并且竞争结合相同的细胞膜受体。这些发现表明生长抑制剂和β型转化生长因子是相似的分子。数据还表明，相同的纯化多肽可以刺激或抑制细胞增殖，具体取决于实验条件。
Purified growth inhibitor from BSC-1 cells and type beta transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type beta transforming growth factor are similar molecules. The data also show that the same purified polypeptide can either stimulate or inhibit cell proliferation depending on the experimental conditions.