Integrative control of rectoanal reflex in guinea pigs through lumbar colonic nerves
Integrative control of rectoanal reflex in guinea pigs through lumbar colonic nerves
复制标题
DOI：
10.1152/ajpgi.00497.2001
复制
发表时间：
2002-07-01
影响因子：
4.5
通讯作者：
Takaki, M
中科院分区：
文献类型：
--
作者：
Yamanouchi, M;Shimatani, H;Takaki, M
本研究的目的是分析豚鼠腰交感神经对直肠反射活动的神经调节。用连接压力传感器的球囊记录直肠的机械活动，用特制的应变式力传感器记录内肛门括约肌（IAS）的机械活动。逐渐和持续的直肠扩张引起直肠反射，引起直肠胆碱能收缩和IAS的同步氮能松弛。腰结肠神经切片增强直肠收缩和IAS松弛。第13胸椎束段消除直肠收缩和IAS松弛，但腰结肠神经段恢复直肠收缩和IAS松弛。腰交感神经切除术和骶索穿刺大大减少了直肠收缩和IAS松弛，但内在反射成分仍然存在。n - g -硝基- l -精氨酸甲酯增强直肠内反射介导的收缩，消除反射介导的IAS松弛，转化为胆碱能收缩。目前的结果表明，外源性腰椎抑制性流出通过腰结肠神经引起直肠反射的明显抑制。
The aim of the present study was to analyze the neuromodulation of rectoanal reflex activity by lumbar sympathetic nerves in guinea pigs. The mechanical activities of the rectum were recorded with a balloon connected to a pressure transducer, and those of the internal anal sphincter (IAS) were recorded with a custom-made strain gauge force transducer. Gradual and sustained rectal distension evoked the rectoanal reflex, causing cholinergic contractions of the rectum and synchronous nitrergic relaxations of the IAS. Section of the lumbar colonic nerves enhanced both rectal contractions and IAS relaxations. Section of the 13th thoracic cord abolished both rectal contractions and IAS relaxations, but section of the lumbar colonic nerves restored them. Lumbar sympathectomy and pithing sacral cords greatly diminished these rectal contractions and IAS relaxations, but the intrinsic reflex component remained. N-G-nitro-L-arginine methyl ester enhanced the intrinsic reflex-mediated contraction of the rectum and abolished reflex-mediated relaxation of the IAS and converted into cholinergic contractions. The present results indicate that the extrinsic lumbar inhibitory outflow causes marked inhibition of the rectoanal reflex via the lumbar colonic nerves.