Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway
Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway
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DOI：
10.1016/s0014-5793(96)01404-4
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发表时间：
1997-01-06
期刊：
影响因子：
3.5
通讯作者：
Rohmer, M
中科院分区：
文献类型：
--
作者：
Lichtenthaler, HK;Schwender, J;Rohmer, M
异戊烯基二磷酸(IPP)是异戊二烯类化合物的生物C-5前体。通过[1-C-13]葡萄糖的标记实验，高等植物具有两条不同的生物合成IPP的途径：细胞质中的甾醇通过乙酸酯/甲戊酸途径合成，而叶绿体结合的异戊二烯类化合物(β-胡萝卜素、叶黄素、叶绿素的戊烯基链和叶绿体-9)通过一种新的IPP生物合成途径(磷酸甘油醛/丙酮酸途径)合成，这是在真细菌和绿藻中首次发现的。高等植物类异戊二烯生物合成的二分法可以合理地解释以前关于叶绿体类异戊二烯生物合成的奇怪和不确定的结果，到目前为止，这些结果主要是在甲戊酸途径区隔模型的框架内解释的。
Isopentenyl diphosphate (IPP) is the biological C-5 precursor of isoprenoids. By labeling experiments using [1-C-13]glucose, higher plants were shown to possess two distinct biosynthetic routes for IPP biosynthesis: while the cytoplasmic sterols were formed via the acetate/mevalonate pathway, the chloroplast-bound isoprenoids (beta-carotene, lutein, prenyl chains of chlorophylls and plastoquinone-9) were synthesized via a novel IPP biosynthesis pathway (glyceraldehyde phosphate/pyruvate pathway) which was first found in eubacteria and a green alga. The dichotomy in isoprenoid biosynthesis in higher plants allows a reasonable interpretation of previous odd and inconclusive results concerning the biosynthesis of chloroplast isoprenoids, which so far had mainly been interpreted in the frame of models using compartmentation of the mevalonate pathway.