Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas
Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas
复制标题
DOI：
10.1093/annonc/mdm453
复制
发表时间：
2008-02-01
影响因子：
50.5
通讯作者：
Kallioniemi, A.
中科院分区：
文献类型：
--
作者：
Alarmo, E. -L.;Korhonen, T.;Kallioniemi, A.
背景：我们最近发现骨形态发生蛋白7（BMP 7）在原发性乳腺肿瘤中过度表达。在这里，我们探讨了BMP 7表达在乳腺癌的临床意义。材料和方法：本研究包括483例乳腺癌患者的完整的临床病理信息和长达15年的随访。样本包含241个小叶癌，242个导管癌，和40个局部复发。结果：47%的原发灶和13%的局部复发灶中均有BMP 7的表达。原发灶BMP 7的表达高于相应的局部复发灶（P = 0.004）。BMP 7的表达依赖于肿瘤的亚型; 57%的小叶癌，但只有37%的导管癌的BMP 7阳性（P = 0.0001）。BMP-7表达与骨转移的加速形成有关（P = 0.040），尤其是在导管癌中（P = 0.033），多因素分析证实BMP 7是早期骨转移发展的独立预后指标（P = 0.032）。BMP 7与骨转移形成明显相关，因此可能在鉴定骨转移风险增加的患者中具有临床实用性。这是骨诱导因子BMP 7首次与乳腺癌的骨转移过程有关。
Background: We recently showed that bone morphogenetic protein 7 (BMP7) is overexpressed in primary breast tumors. Here we explored the clinical significance of BMP7 expression in breast cancer.Materials and methods: This study included 483 breast cancer patients with complete clinicopathological information and up to 15 years of follow-up. Samples contained 241 lobular carcinomas, 242 ductal carcinomas, and 40 local recurrences. BMP7 protein expression was determined using immunohistochemistry.Results: BMP7 was expressed in 47% of the primary tumor samples and 13% of the local recurrences. The primary tumors expressed BMP7 more often than the corresponding local recurrences (P = 0.004). BMP7 expression was dependent on the tumor subtype; 57% of the lobular carcinomas but only 37% of the ductal carcinomas were BMP7 positive (P = 0.0001). BMP7 expression was associated with accelerated bone metastasis formation (P = 0.040), especially in ductal carcinomas (P = 0.033), and multivariate analysis confirmed that BMP7 is an independent prognostic indicator for early bone metastasis development (P = 0.032).Conclusion: BMP7 is clearly associated with bone metastasis formation and thus might have clinical utility in identification of patients with increased risk of bone metastasis. This is the first time that bone inducing factor BMP7 has been linked to the bone metastasis process in breast cancer.