Molecular design of inorganic-binding polypeptides
Molecular design of inorganic-binding polypeptides
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DOI：
10.1557/mrs2008.103
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发表时间：
2008-05-01
期刊：
影响因子：
5
通讯作者：
Tamerler, Candan
中科院分区：
文献类型：
--
作者：
Evans, John Spencer;Samudrala, Ram;Tamerler, Candan
多肽在无机底物上的可控结合和组装是生物纳米技术和生物材料工程的核心。多肽为发展未来的无机材料和体系提供了几个独特的优势。首先，工程多肽可以分子识别无机表面，这些表面可以通过形状、结晶学、矿物学和化学来区分。其次，多肽能够在特定的材料表面自组装，从而形成可寻址的分子结构。最后，基因工程多肽为其功能修饰提供了多种策略。在本文中，我们总结了组合多肽序列选择和无机材料识别和亲和力所涉及的细节和机制，并概述了有助于推进这一新兴领域的实验和理论方法和概念。
Controlled binding and assembly of peptides onto inorganic substrates is at the core of bionanotechnology and biological-materials engineering. Peptides offer several unique advantages for developing future inorganic materials and systems. First, engineered polypeptides can molecularly recognize inorganic surfaces that are distinguishable by shape, crystallography, mineralogy, and chemistry. Second, polypeptides are capable of self-assembly on specific material surfaces leading to addressable molecular architectures. Finally, genetically engineered peptides offer multiple strategies for their functional modification. In this article, we summarize the details and mechanisms involved in combinatorial-polypeptide sequence selection and inorganic- material recognition and affinity, and outline experimental and theoretical approaches and concepts that will help advance this emerging field.