Hepatic fatty acid-binding protein mRNA is regulated by growth hormone.
Hepatic fatty acid-binding protein mRNA is regulated by growth hormone.
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肝脂肪酸结合蛋白 mRNA 受生长激素调节。
DOI：
10.1080/07315724.1993.10718354
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发表时间：
1993
影响因子：
3.5
通讯作者：
Seelig,S
中科院分区：
文献类型：
--
作者：
Berry,SA;Yoon,JB;List,J;Seelig,S
肝脏脂肪酸结合蛋白(FABP)是多种丰富的蛋白质之一，可能参与脂肪酸的摄取和利用。利用差异杂交技术筛选生长激素反应基因产物，分离得到一个互补脱氧核糖核酸(CDNAs)，证实为肝脏FABP基因片段。去垂体组大鼠肝脏FABP信使核糖核酸水平下降60%，给予生长激素可恢复肝脏FABP信使核糖核酸表达。其他脑下垂体激素并没有改变这些表达的变化。对生长激素的反应出现在给药后4小时内。在发育过程中，大鼠肝脏中FABP mRNA的表达在胚胎晚期较低，到出生第2天时增加到成年值的40%。成体水平的显著增加直到第25天之后才发生，那时基本上完成了断奶。生长激素对大鼠肝脏FABP基因表达的影响可能在脂肪酸摄取和代谢的复杂调控中起重要作用。
Hepatic fatty acid-binding protein (FABP) is one of several abundant proteins which may participate in fatty acid uptake and utilization. Using differential hybridization to screen for growth hormone-responsive gene products, a complementary deoxyribonucleic acid (cDNA) was isolated which proved to be a hepatic FABP cDNA fragment. Hypophysectomy caused a 60% reduction in hepatic FABP messenger ribonucleic acid (mRNA) levels in rat liver, and growth hormone administration to hypophysectomized rats resulted in restoration of the expression of hepatic FABP mRNA. Other pituitary hormones did not alter these changes in expression. The response to growth hormone occurred within 4 hours of administration. During development, expression of hepatic FABP mRNA in rat liver was low in late fetal life, with increases to 40% of adult values by day 2 of life. Significant increases to adult levels did not occur until after day 25, when weaning is essentially completed. Alteration of hepatic FABP mRNA expression by growth hormone in rat liver may be important in the complex regulation of fatty acid uptake and metabolism.