Epidemiology of premalignant gastric lesions: Implications for the development of screening and surveillance strategies
Epidemiology of premalignant gastric lesions: Implications for the development of screening and surveillance strategies
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DOI：
10.1111/j.1523-5378.2007.00562.x
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发表时间：
2007-11-01
期刊：
影响因子：
4.4
通讯作者：
Kulpers, Ernst J.
中科院分区：
文献类型：
--
作者：
de Vries, Annemarie C.;Kulpers, Ernst J.
胃癌是世界上最常见的癌症之一;然而，胃癌的发病率在不同的地理区域之间差异很大。由于胃癌通常在晚期才被诊断出来，因此该疾病导致相当大的发病率和死亡率。为了在早期发现胃癌并治愈，筛查和监测似乎是必要的。胃癌前病变是肠型胃腺癌发生的危险因素。在一个多步骤级联反应中，慢性幽门螺杆菌诱导的胃炎经过萎缩性胃炎、肠上皮化生和异型增生的癌前阶段，最终发展为胃癌。因此，该级联反应可能为胃癌的早期发现和治疗提供依据。胃癌和癌前病变的流行病学应指导筛查和监测策略的制定，因为在胃癌发病率低和高的国家需要不同的方法。
Gastric cancer is one of the most common cancers worldwide; however, gastric cancer incidence varies greatly between different geographic areas. As gastric cancer is usually diagnosed at an advanced stage, the disease causes considerable morbidity and mortality. To detect gastric carcinomas at an early and curable stage, screening and surveillance seem necessary. Premalignant gastric lesions are well known risk factors for the development of intestinal type gastric adenocarcinomas. In a multistep cascade, chronic Helicobacter pylori-induced gastritis progresses through premalignant stages of atrophic gastritis, intestinal metaplasia and dysplasia, to eventually gastric cancer. Therefore, this cascade may provide a basis for early detection and treatment of gastric cancer. Epidemiology of gastric cancer and premalignant gastric lesions should guide the development of screening and surveillance strategies, as distinct approaches are required in countries with low and high gastric cancer incidences.