Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
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DOI：
10.1128/jvi.75.13.5965-5976.2001
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发表时间：
2001-07-01
影响因子：
5.4
通讯作者：
Welsh, RM
中科院分区：
文献类型：
--
作者：
McNally, JM;Zarozinski, CC;Welsh, RM
旨在区分病毒特异性和非病毒特异性T细胞的实验表明，旁观者T细胞在强烈的T细胞反应后经历了凋亡和大量的磨损。CD8记忆性T细胞(CD8+、CD44(Hi))受影响最大，在急性病毒感染期间，明确定义为非病毒特异性的转基因T细胞数量减少，细胞凋亡率增加。此外，使用携带淋巴细胞性脉络膜脑膜炎病毒(LCMV)的小鼠，由于缺乏LCMV特异性T细胞，非病毒特异性记忆CD8 T细胞显著减少，这与过继转移的病毒特异性T细胞增殖导致的细胞凋亡增加有关。感染早期T细胞的磨损与α/β干扰素峰值有关，干扰素诱导剂聚(I：C)可引起正常小鼠CD8(+)CD44(Hi)T细胞的凋亡和磨损，而在干扰素α/β受体缺陷小鼠中则不能。旁观者T细胞的凋亡磨损可能为感染期间T细胞抗原特异性的扩张腾出空间，并可能在一定程度上解释当宿主经历后续感染时发生的T细胞记忆的丧失。
Experiments designed to distinguish virus-specific from non-virus-specific T cells show-ed that bystander T cells underwent apoptosis and substantial attrition in the wake of a strong T-cell response. Memory CD8 T cells (CD8(+) CD44(hi)) were most affected, During acute viral infection, transgenic T cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. Also, use of lymphocytic choriomeningitis virus (LCMV) carrier mice, which lack LCMV-specific T cells, showed a significant decline in non-virus-specific memory CD8 T cells that correlated to an increase in apoptosis in response to the proliferation of adoptively transferred virus-specific T cells. Attrition of T cells early during infection correlated with the alpha/beta interferon (IFN-alpha/beta) peak, and the IFN inducer poly (I:C) caused apoptosis and attrition of CD8(+) CD44(hi) T cells in normal mice but not in IFN-alpha/beta receptor-deficient mice. Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections.