Sub-regional hippocampal vulnerability in various animal models leading to cognitive dysfunction
Sub-regional hippocampal vulnerability in various animal models leading to cognitive dysfunction
复制标题
DOI：
10.1007/s007020050107
复制
发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Levy, A
中科院分区：
文献类型：
--
作者：
Kadar, T;Dachir, S;Levy, A
不同的动物模型，涉及不同的大脑损伤，导致记忆缺陷，这可以用行为测试来测量。在大量的研究中，我们使用了五种不同的大鼠实验模型，发现认知功能障碍总是伴随着海马CA1和CA3锥体细胞的变性。然而，在这两个模型中，受影响最大的区域会随着模型的不同而变化。本论文描述并比较了下列实验模型中海马的形态学改变：正常衰老、缺氧、长期皮质酮给药、脑缺血和胆碱酯酶（ChE）抑制。综上所述，许多海马神经元都受到了严重的损伤，但CA3锥体细胞在正常衰老和低压缺氧后受到的影响最大，而CA1细胞在皮质酮给药、全身缺血和ChE抑制后受到的影响尤为严重。几种机制，可能涉及病变的不同过程正在考虑：脑氧和葡萄糖，谷氨酸神经毒性和钙受累。预计阐明CA1和CA3海马亚区在各种实验模型中的具体作用可能有助于理解诸如年龄相关的神经元变性等过程并有助于其预防。
Various animal models, involving different brain insults, lead to memory deficits, which can be measured using behavioral tests. In numerous studies, using five different experimental models in rats, we have found that cognitive dysfunction is invariably accompanied by hippocampal CA1 and CA3 pyramidal cells degeneration. However, of these two, the most affected area changes from one model to the other. The present manuscript describes and compares the morphological alterations within the hippocampus in the following experimental models: normal aging, hypoxia, prolonged corticosterone administration, brain ischemia and cholinesterase (ChE) inhibition. In all the above, many hippocampal neurons were severely damaged, however, CA3 pyramidal cells were mostly affected in normal aging and following hypobaric hypoxia, whereas CA1 cells were especially affected following corticosterone administration, global ischemia and ChE inhibition.Several mechanisms, which might be involved in the diverse courses of the lesions are being considered: cerebral oxygen and glucose, glutamate neurotoxicity and calcium involvement. It is anticipated that elucidation of the specific role of CA1 and CA3 hippocampal sub-fields in the various experimental models might help in understanding processes such as age-related neuronal degeneration and assist in their prevention.