Regulation of B-cell differentiation: interactions of factors and corresponding receptors.
Regulation of B-cell differentiation: interactions of factors and corresponding receptors.
复制标题
B 细胞分化的调节：因子和相应受体的相互作用。
作者：
T. Hamaoka;S. Ono
对标称抗原如半抗原-载体缀合物的抗体应答涉及半抗原特异性B细胞和载体特异性辅助T细胞的合作（1-4）。除了载体特异性外，辅助T细胞还识别抗原呈递细胞和B细胞上II类主要组织相容性复合体（MHC）中基因编码的决定簇（5-13）。辅助性T细胞和抗原提呈辅助细胞（APC）之间的相互作用在遗传上受到主要组织相容性复合体产物的限制（14-16）。然而，据报道，辅助T细胞和B细胞之间的细胞相互作用受自身MHC产物的限制（5-7，10-12，17）或不受MHC元件的限制（18，19）。由于MHC产物所施加的遗传限制被认为是T细胞识别非T细胞（APC）表达的自身MHC决定簇的必要条件，因此可以基于T细胞是否必须识别B细胞表达的MHC决定簇以触发它们分泌抗体来解释该争议。自从最初描述T细胞在抗原依赖性刺激B细胞中的作用以来，大量的努力已经转向阐明辅助性T细胞发挥功能的机制。一系列研究表明，B细胞群的一些成员参与了与辅助性T细胞的同源细胞相互作用。同源相互作用是指抗原和B细胞表面上的II类MHC分子两者的识别作为活化的要求。其他
The antibody response to nominal antigen such as hapten-carrier con jugates involves the cooperation of hapten-specific B cells and carrier specific helper T cells (1-4). In addition to the carrier specificity, helper T cells recognize determinants encoded by genes in the class-II major histocompatibility complex (MHC) on antigen-presenting cells as well as on B cells (5-13). The interaction between helper T cells and antigen presenting accessory cells (APC) is genetically restricted by products of the major histocompatibility complex (14-16). However, the cellular interac tions between helper T cells and B cells have been reported as restricted by self-MHC products (5-7, 10-12, 17) or not restricted by the MHC elements (18, 19). Since genetic restrictions imposed by products of the MHC are considered as a requirement for the recognition by T cells of self-MHC determinants expressed by non-T cells (APC), this controversy can be explained on the basis of whether T cells must necessarily recognize the MHC determinants expressed by B cells in order to trigger them to secrete antibodies. Since the original description of a role for T cells in the antigen dependent stimulation of B cells, a great deal of effort has gone toward elucidating the mechanism by which helper T cells function. A series of studies demonstrated that some members of the B-cell population participate in cognate cellular interactions with helper T cells. Cognate interaction refers to the recognition of both antigen and a class-II MHC molecule on the B-cell surface as a requirement for activation. Other