Straightforward novel one-pot enaminone and pyrimidine syntheses by coupling-addition-cyclocondensation sequences
Straightforward novel one-pot enaminone and pyrimidine syntheses by coupling-addition-cyclocondensation sequences
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DOI：
10.1055/s-2003-42480
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发表时间：
2003-12-18
影响因子：
2.6
通讯作者：
Müller, TJJ
中科院分区：
文献类型：
--
作者：
Karpov, AS;Müller, TJJ
The coupling of acid chlorides 1 with terminal alkynes 2 using only one equivalent (!) of triethylamine under Sonogashira conditions followed by subsequent addition of primary or secondary amines 4 to the intermediate alkynones 3 represents a straightforward one-pot three component access to enaminones 5 under mild conditions and in excellent yields. Furthermore, 2,4-di- and 2.4,6-trisubstituted pyrimidines 7 can be synthesized in moderate to good yields according to a highly flexible coupling-addition-cyclocondensation sequence.
