Developmental changes in somatosensory processing in cerebral palsy and healthy individuals
Developmental changes in somatosensory processing in cerebral palsy and healthy individuals
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DOI：
10.1016/j.clinph.2010.03.010
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发表时间：
2010-08-01
影响因子：
4.7
通讯作者：
Montoya, Pedro
中科院分区：
文献类型：
--
作者：
Riquelme, Inmaculada;Montoya, Pedro
目的：脑瘫（CP）是一种在人类发育过程中引起身体残疾的运动障碍。最近的研究表明，体感缺陷对CP患者来说是一个严重的问题。然而，没有关于年龄对大脑触觉敏感性相关的影响的信息。方法：对15例小儿CP（范围5 ~ 14 y）、14例成人CP（范围22 ~ 55 y）、15例健康儿童（范围5 ~ 14 y）和15例健康成人（范围22 ~ 42 y）的唇部和拇指触觉刺激引起的本体感觉、触觉和疼痛压力阈值以及体感诱发电位（SEP）进行检测。结果：与健康对照相比，CP患儿对非疼痛性刺激的敏感性降低，但对疼痛性刺激的敏感性增强。儿童和成人CP患者的早期SEP振幅（P50和P100）比健康参与者增强。当左右侧身体部位受到刺激时，在CP中观察到功能性半球不对称。结论：数据表明，CP中体感脑处理的改变可能反映了体感皮层兴奋性的增强。意义：体感功能的评估可能对未来脑瘫儿童和成人疼痛主诉的神经调节治疗和运动康复计划有指导意义。(C) 2010年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Cerebral palsy (CP) is a motor disorder that causes physical disability in human development. Recent work has shown that somatosensory deficits are a serious problem for people with CP. There is however no information about the influence of age on brain correlates of tactile sensitivity.Methods: Proprioception, touch and pain pressure thresholds, as well as somatosensory evoked potentials (SEP) elicited by tactile stimulation in lips and thumbs were examined in 15 children with CP (range 5-14 y), 14 adults with CP (range 22-55 y), 15 healthy children (range 5-14 y), and 15 healthy adults (range 22-42 y).Results: Children with CP as compared to healthy controls showed more reduced sensitivity for non-painful stimuli, but enhanced sensitivity for painful stimuli. Early SEP amplitudes (P50 and P100) were more enhanced in children and adults with CP than in healthy participants. A functional hemispheric asymmetry was observed in CP when left-and right-side body parts were stimulated.Conclusions: Data suggest the possibility that altered somatosensory brain processing in CP might be reflecting an enhanced excitability of the somatosensory cortex.Significance: Assessment of somatosensory functions may have implications for future neuromodulatory treatment of pain complaints and motor rehabilitation programs in children and adults with cerebral palsy. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.