Unimolecular micelles based on hyperbranched polycarbohydrate cores
Unimolecular micelles based on hyperbranched polycarbohydrate cores
复制标题
DOI：
10.1039/b819748b
复制
发表时间：
2009-05
期刊：
影响因子：
3.4
通讯作者：
T. Satoh
中科院分区：
文献类型：
--
作者：
T. Satoh
本文详细介绍了具有单分子胶束特征的新型两亲性超支化聚合物的制备及其包封-释放性能，这种聚合物被称为单分子胶束或单分子纳米胶囊。由亲水性超支化聚碳水化合物核和疏水壳组成的两亲性超支化聚合物具有包裹亲水性客体分子和控制被包裹客体分子释放的能力，例如由超支化D-甘露聚糖核和聚L-丙交酯壳组成的可生物降解的单分子反胶束，以及由超支化D-葡聚糖核和L亮氨酸乙醚壳组成的pH敏感型单分子反胶束。以超支化聚苏糖醇为亲水核，三苯基为疏水壳的两亲性超支化聚合物以单分子纳米胶囊的形式存在，对客体分子具有很强的包封性。具有疏水核的两亲性超支化聚合物和亲水性的L-天冬氨酸壳层对水中的疏水分子具有包封性。因此，超支化聚合物被认为是单分子胶束或单分子纳米胶囊树枝状核心分子的良好候选者。
This Review article details the preparation and encapsulation–release properties of novel amphiphilic hyperbranched polymers with a micellar characteristic as a single molecule, which are referred to as “unimolecular micelles” or “unimolecular nanocapsules”. Amphiphilic hyperbranched polymers consisting of a hydrophilic hyperbranched polycarbohydrate core and hydrophobic shell possess an ability to encapsulate hydrophilic guest molecules and control the release of the encapsulated guest molecules, e.g., a biodegradable unimolecular reversed micelle consisting of a hyperbranched D-mannan core and a poly(L-lactide) shell, and the pH-sensitive unimolecular reversed micelle consisting of a hyperbranched D-glucan core and L-leucine ethyl ether shell. An amphiphilic hyperbranched polymer consisting of a hyperbranched polythreitol as the hydrophilic core and trityl groups as the hydrophobic shell acts as unimolecular nanocapsule, and shows a high encapsulation ability for guest molecules. Amphiphilic hyperbranched polymer with a hydrophobic core and hydrophilic L-aspartic acid shell possess encapsulation properties for hydrophobic molecules in water. Hence, hyperbranched polymers are found to be good candidates for the dendritic core molecule of a unimolecular micelle or unimolecular nanocapsule.