Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin's lymphoma
Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin's lymphoma
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DOI：
10.3324/haematol.2011.050138
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发表时间：
2012-02-01
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影响因子：
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通讯作者：
Markovic, Svetomir N.
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作者：
Porrata, Luis F.;Ristow, Kay;Markovic, Svetomir N.
背景淋巴细胞减少症和肿瘤相关巨噬细胞是经典霍奇金淋巴瘤生存的负面预后因素。因此，我们研究了外周血淋巴细胞绝对计数/单核细胞绝对计数比率在诊断是否影响经典霍奇金淋巴瘤的生存率。设计和MethodsWe研究了476例连续的经典霍奇金淋巴瘤患者，随后在马约诊所从1974年至2010年。受试者工作特征曲线和曲线下面积被用来确定临界值的绝对淋巴细胞计数/绝对单核细胞计数比率在诊断，而比例风险模型被用来比较生存的基础上的绝对淋巴细胞计数/绝对单核细胞计数比率在diagnosis.ResultsThe中位随访期为5.6年（范围，0.1-33.7年）。诊断时淋巴细胞绝对计数/单核细胞绝对计数比值≥ 1.1是生存的最佳截止值，曲线下面积为0.91（95%置信区间，0.86至0.96），灵敏度为90%（95%置信区间，85%至96%），特异性为79%（95%置信区间，73%至88%）。诊断时淋巴细胞绝对计数/单核细胞绝对计数比值是影响总生存率的独立预后因素（危险比，0.18; 95%可信区间，0.08 ~ 0.38，P
BackgroundLymphopenia and tumor-associated macrophages are negative prognostic factors for survival in classical Hodgkin's lymphoma. We, therefore, studied whether the peripheral blood absolute lymphocyte count/absolute monocyte count ratio at diagnosis affects survival in classical Hodgkin's lymphoma.Design and MethodsWe studied 476 consecutive patients with classical Hodgkin's lymphoma followed at the Mayo Clinic from 1974 to 2010. Receiver operating characteristic curves and area under the curve were used to determine cut-off values for the absolute lymphocyte count/absolute monocyte count ratio at diagnosis, while proportional hazards models were used to compare survival based on the absolute lymphocyte count/absolute monocyte count ratio at diagnosis.ResultsThe median follow-up period was 5.6 years (range, 0.1-33.7 years). An absolute lymphocyte count/absolute monocyte count ratio at diagnosis of 1.1 or more was the best cut-off value for survival with an area under the curve of 0.91 (95% confidence interval, 0.86 to 0.96), a sensitivity of 90% (95% confidence interval, 85% to 96%) and specificity of 79% (95% confidence interval, 73% to 88%). Absolute lymphocyte count/absolute monocyte count ratio at diagnosis was an independent prognostic factor for overall survival (hazard ratio, 0.18; 95% confidence interval, 0.08 to 0.38, P