Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers.
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers.
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DOI：
10.1007/s13346-021-01079-1
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发表时间：
2021-12
影响因子：
5.4
通讯作者：
Munson JM
中科院分区：
文献类型：
--
作者：
Turk OM;Woodall RC;Gutova M;Brown CE;Rockne RC;Munson JM
基于细胞的大脑疗法有望治疗包括神经退行性疾病和癌症在内的多种脑部疾病。为了进入脑实质，根据输送途径，必须克服多种生理障碍。具体而言，血脑屏障几十年来一直是药物递送的主要困难，并且仍然对治疗细胞的递送提出挑战。其他屏障，包括血脑脊液屏障和淋巴脑屏障，研究较少，但可能为治疗提供特定的挑战或机会。在这里，我们讨论大脑的障碍以及目前提供基于细胞的疗法（包括工程 T 细胞、树突状细胞和干细胞）来治疗疾病的策略。我们特别关注癌症，还重点介绍了当前正在进行的使用细胞疗法治疗疾病的临床试验，其中许多试验显示出治疗一些最致命疾病的希望。
Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to access the brain parenchyma, there are multiple physiological barriers that must be overcome depending on the route of delivery. Specifically, the blood-brain barrier has been a major difficulty in drug delivery for decades, and it still presents a challenge for the delivery of therapeutic cells. Other barriers, including the blood-cerebrospinal fluid barrier and lymphatic-brain barrier are less explored, but may offer specific challenges or opportunities for therapeutic delivery. Here we discuss the barriers to the brain and the strategies currently in place to deliver cell-based therapies, including engineered T cells, dendritic cells, and stem cells, to treat diseases. With a particular focus on cancers, we also highlight the current ongoing clinical trials that use cell-based therapies to treat disease, many of which show promise at treating some of the deadliest illnesses.