Serotonin, 5-hydroxyindoleacetic acid and serotonin transporter in blood peripheral lymphocytes of patients with generalized anxiety disorder
Serotonin, 5-hydroxyindoleacetic acid and serotonin transporter in blood peripheral lymphocytes of patients with generalized anxiety disorder
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DOI：
10.1016/s1567-5769(02)00025-5
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发表时间：
2002-06-01
影响因子：
5.6
通讯作者：
Lima, L
中科院分区：
文献类型：
--
作者：
Hernández, E;Lastra, S;Lima, L
病理性焦虑中有几种免疫系统的改变，如广泛性焦虑、恐慌和强迫症。由于5 -羟色胺转运体是外周血淋巴细胞的标志物，在重度抑郁症中被修饰，本研究的目的是通过[H-3]帕罗西汀与对照组和广泛性焦虑障碍患者外周血淋巴细胞膜制剂的结合来评估5 -羟色胺转运体。转运体的数量和对配体的亲和力在两组之间没有差异。测定富血小板血浆、贫血小板血浆和淋巴细胞中血清素和5-羟基吲哚乙酸（5HIAA）含量。与对照组相比，患者没有发现明显的变化。然而，在患者中，血小板缺乏血浆中的血清素浓度与淋巴细胞中的血清素浓度之间存在显著的正相关，而在对照组中则没有。这一发现可能表明转运体功能调节不良，血清素血浆浓度可能影响淋巴细胞血清素浓度。先前的研究结果表明，重度抑郁症患者这些细胞中的血清素转运体减少；然而，在广泛性焦虑障碍中，转运体的数量没有改变，尽管血清素转运体的功能效率可能会改变。(C) 2002 Elsevier Science B.V.版权所有
Several immune system modifications have been reported in pathological anxiety, such as generalized anxiety, panic and obsessive-compulsive disorders. Since serotonin transporter is a marker of peripheral blood lymphocytes and it is modified in major depression, the aim of the present work was to evaluate this transporter by the binding of [H-3]paroxetine to membrane preparations of blood peripheral lymphocytes from control subjects and patients with generalized anxiety disorder. The number of transporters and the affinity for the ligand did not differ among the two groups. Serotonin and 5-hydroxyindoleacetic acid (5HIAA) were determined in platelet-rich and -poor plasma, and in lymphocytes. Nonsignificant changes were found in the patients as compared to controls. However, there was a significant positive correlation between serotonin concentration in platelet-poor plasma and in lymphocytes in the patients, but not in the controls. This finding might be an indication of a poor regulation of the transporter function by which serotonin plasma concentration might influence lymphocyte serotonin concentration. Previous results indicate that serotonin transporter is reduced in these cells in major depression disorder; however, in generalized anxiety disorder, the number of transporters was not modified, although the functional efficiency of serotonin transporter might be altered. (C) 2002 Elsevier Science B.V. All rights reserved.