Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability
Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability
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DOI：
10.1016/j.physbeh.2017.06.003
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发表时间：
2017-10-01
影响因子：
2.9
通讯作者：
Clinard, Catherine T.
中科院分区：
文献类型：
--
作者：
Cooper, Matthew A.;Seddighi, Sahba;Clinard, Catherine T.
了解控制压力抵抗力和脆弱性的细胞机制是确定预防和治疗压力相关精神疾病的新目标的重要一步。在叙利亚仓鼠中，优势动物和从属动物对社会失败应激表现出不同的行为和生理反应，优势动物表现为应激抵抗性，而从属动物表现为应激易感性。我们之前发现，在调节压力应对的大脑区域中，优势仓鼠和从属仓鼠表现出不同水平的失败诱导神经活动，尽管应激易感性的状态依赖差异在多大程度上推广到非社会压力源尚不清楚。在这项研究中，将雄性叙利亚仓鼠暴露在急性身体约束下30分钟，并在选定的大脑区域量化约束诱导的c-Fos免疫反应性。与优势动物相比，劣势动物在边缘下（IL）、边缘前（PL）和腹侧内侧杏仁核（vMeA）中表现出较少的抑制诱导的c-Fos免疫反应性，这与社会失败应激的地位依赖性效应是一致的。隶属动物在中隔背核（rvDRN）的前腹侧c-Fos免疫反应性没有增加，这与社会失败应激的影响相反。这些发现表明，神经活动的状态依赖性变化以大脑区域依赖性的方式从一种压力源扩展到另一种压力源。这些发现进一步表明，虽然一些神经回路可能支持一种普遍形式的应激抵抗，但其他神经回路可能提供对特定应激源的抵抗。
Understanding the cellular mechanisms that control resistance and vulnerability to stress is an important step toward identifying novel targets for the prevention and treatment of stress-related mental illness. In Syrian hamsters, dominant and subordinate animals exhibit different behavioral and physiological responses to social defeat stress, with dominants showing stress resistance and subordinates showing stress vulnerability. We previously found that dominant and subordinate hamsters show different levels of defeat-induced neural activity in brain regions that modulate coping with stress, although the extent to which status-dependent differences in stress vulnerability generalize to non-social stressors is unknown. In this study, dominant, subordinate, and control male Syrian hamsters were exposed to acute physical restraint for 30 min and restraint-induced c-Fos immunoreactivity was quantified in select brain regions. Subordinate animals showed less restraint-induced c-Fos immunoreactivity in the infralimbic (IL), prelimbic (PL), and ventral medial amygdala (vMeA) compared to dominants, which is consistent with the status-dependent effects of social defeat stress. Subordinate animals did not show increased c-Fos immunoreactivity in the rostroventral dorsal raphe nucleus (rvDRN), which is in contrast to the effects of social defeat stress. These findings indicate that status-dependent changes in neural activity generalize from one stressor to another in a brain region-dependent manner. These findings further suggest that while some neural circuits may support a generalized form of stress resistance, others may provide resistance to specific stressors.