Oscillatory cortical activity related to voluntary muscle relaxation: Influence of normal aging
Oscillatory cortical activity related to voluntary muscle relaxation: Influence of normal aging
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DOI：
10.1016/j.clinph.2006.05.017
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发表时间：
2006-09-01
影响因子：
4.7
通讯作者：
Derambure, P.
中科院分区：
文献类型：
--
作者：
Labyt, E.;Cassim, F.;Derambure, P.
目的：在本研究中，我们旨在调查与作为参考运动的肌肉收缩相比，自定进度的肌肉纯粹放松引起的皮质振荡活动是否存在与年龄相关的差异。方法：在 10 名年轻和 10 名老年右手健康受试者中记录了与随意肌肉收缩和放松相关的事件相关（去）同步（ERD/ERS）。肌肉放松任务包括保持手腕伸展的自愿放松，没有任何明显的相关肌肉收缩。肌肉收缩任务对应于自我启动的短暂手腕伸展。结果：与年轻受试者相比，老年受试者中，肌肉松弛之前的 mu 和 beta ERD 更为普遍，在对侧额中央和顶中央区域 (p < 0.05) 以及同侧区域 (p < 0.05) 开始明显更早。 β 同步显着减弱（p < 0.05）。结论：这些结果表明，随着正常衰老，抑制性运动系统发生了改变，运动后感觉输入处理也发生了改变。这些改变伴随着补偿机制。意义：肌肉松弛不同阶段的这些与年龄相关的变化可能有助于解释正常衰老过程中观察到的整体感觉运动减慢。 (c) 2006 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: In this study we aimed to investigate if there are age-related differences in cortical oscillatory activity induced by self-paced muscular pure relaxation in comparison with muscle contraction as reference movement.Methods: Event-related (de)synchronization (ERD/ERS) have been recorded related to voluntary muscle contraction and relaxation in 10 young and 10 elderly right-handed healthy subjects. The muscle relaxation task consisted in a voluntary relaxation of maintained wrist extension without any overt, associated muscle contraction. The muscle contraction task corresponded to a self-initiated brief wrist extension.Results: In elderly subjects compared to young ones, mu and beta ERD preceding muscular relaxation was more widespread, beginning significantly earlier over contralateral frontocentral and parietocentral regions (p < 0.05) as well as over ipsilateral regions (p < 0.05). The beta synchronization was significantly attenuated (p < 0.05).Conclusions: These results suggest an alteration of inhibitory motor systems and an altered post-movement somesthetic inputs processing with normal aging. These alterations were accompanied by compensatory mechanisms. Significance: These age-related alterations during different phases of muscle relaxation could participate to explain global sensorimotor slowing observed with normal aging. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.