Salivary response to food in humans and its effect on gastric acid secretion.
Salivary response to food in humans and its effect on gastric acid secretion.
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人类唾液对食物的反应及其对胃酸分泌的影响。
DOI：
10.1152/ajpgi.1986.250.1.g85
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Feldman,M
中科院分区：
文献类型：
--
作者：
Richardson,CT;Feldman,M
这些研究的目的是确定人类对食物分泌的唾液量，并评估唾液对餐后胃酸分泌的影响。受试者咀嚼并吐出一顿开胃的牛排和炸薯条（改良的假喂养），假喂期间食物重量的增加代表唾液分泌。改良假喂养期间，平均唾液流量从基础的37.1 ml/h上升到167.3 ml/h （P < 0.001）。嚼口香糖增加唾液分泌的程度与改良假喂养大致相同，而嚼塑料管引起的唾液流量增加要小得多。静脉输注乙二酚（50微克）。公斤。H-1)在刺激唾液流动方面的效力大约是改良假喂养或嚼口香糖的一半。静脉注射15微克/千克阿托品完全阻断假性喂养的唾液反应。胃内直接注入700 ml氨基酸餐后，大鼠唾液分泌增加约20 ml/h (P < 0.01)，而700 ml生理盐水对胃胀无影响。这些发现表明，胃或小肠上部的食物可能会激活反射或释放一种激素进入循环，从而增加唾液的流动。虽然静脉滴注胃泌素-17对唾液流量没有影响，但注射生长抑素-14使唾液流量增加了15 ml/h （P < 0.02）。唾液中含有约2000 pg/ml的免疫反应性尿胃酮，这是一种非肠外给药的酸分泌抑制剂。（摘要删节250字）
The purpose of these studies was to determine the amount of saliva secreted in response to food in humans and to evaluate the effect of saliva on postprandial gastric acid secretion. Subjects chewed and spat out an appetizing steak and french-fried potato meal (modified sham feeding), with the increase in the weight of the meal during sham feeding taken to represent salivary secretion. Mean salivary flow rose from basal rates of 37.1 ml/h to 167.3 ml/h during modified sham feeding (P less than 0.001). Chewing gum increased salivary secretion to approximately the same extent as modified sham feeding, whereas chewing on plastic tubing caused a much smaller increase in salivary flow. Intravenous infusion of bethanechol (50 micrograms . kg-1 . h-1) was approximately half as potent as modified sham feeding or gum chewing in stimulating salivary flow. The salivary response to sham feeding was completely blocked by 15 micrograms/kg intravenous atropine. Salivary secretion increased approximately 20 ml/h when a 700-ml amino acid meal was infused directly into the stomach (P less than 0.01), whereas gastric distension with 700 ml saline had no effect. These findings suggested that food in the stomach or upper small intestine may activate a reflex or release a hormone into the circulation that augments salivary flow. Although intravenous gastrin-17 infusion had no effect on salivary flow, somatostatin-14 infusion increased salivary flow 15 ml/h (P less than 0.02). Saliva contained approximately 2,000 pg/ml immunoreactive urogastrone, an inhibitor of acid secretion when administered parenterally.(ABSTRACT TRUNCATED AT 250 WORDS)