Cigarette smoking, alcohol drinking and the risk of gallbladder cancer death: A prospective cohort study in Japan
Cigarette smoking, alcohol drinking and the risk of gallbladder cancer death: A prospective cohort study in Japan
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DOI：
10.1002/ijc.23159
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发表时间：
2008-02-15
影响因子：
6.4
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Yagyu, Kiyoko;Kikuchi, Shogo;Tamakoshi, Akiko
胆囊癌是一种罕见的癌症，预后不良，迄今为止几乎没有发现危险因素。这项前瞻性研究旨在评估吸烟和饮酒与胆囊癌死亡风险的关系。从1988年至1900年，在日本全国45个地区进行了基线调查，使用自填式问卷，对年龄在40-89岁的113，496名参与者（65，740名女性）进行了15年的跟踪调查。在随访期间，观察到165例胆囊癌死亡（95名女性）。在女性中，调整年龄和饮酒后，当前吸烟者的风险比（HR）[95%置信区间：95%CI]为2.00 [0.91-4.42]。饮酒与风险之间没有明确的联系。在男性中，当前吸烟者的HR为2.27 [1.05-4.90]。每天吸烟21支或更多的人和801- 1000年吸烟的人的HR分别为3.18 [1.18-8.53]和3.44 [1.40-8.45]，并且观察到这种风险与每天吸烟数量之间存在正线性关系（趋势p = 0.007）或“平均年龄”（趋势p = 0.012）。酒精剂量与风险呈线性相关（趋势p = 0.004），其中每天饮酒72.0 g或更多的人的HR为3.60 [1.29-9.85]。在男性和女性中，吸烟可能会增加死于胆囊癌的风险。饮酒可能会增加男性的风险，但女性似乎不那么真实。(c)2007年Wilev-Liss。Inc.
Gallbladder cancer is a rare cancer with a poor prognosis, and few risk factors have been identified to date. This prospective study was conducted to evaluate the association of cigarette smoking and alcohol consumption with the risk of gallbladder cancer death. A baseline survey in 45 areas throughout Japan was conducted from 1988 to 1900 using a self-administered questionnaire, and a total of 113,496 participants (65,740 women) aged 40-89 years at entry were followed for 15 years. During the follow-up period, 165 gallbladder cancer deaths (95 women) were observed. Among women, the hazard ratio (HR) [95 percent confidence interval: 95% CI] of current smoker was 2.00 [0.91-4.42], when adjusted for age and drinking. There was no clear association between alcohol consumption and the risk. Among men, HR of current smoker was 2.27 [1.05-4.90]. HRs of those who smoked 21 cigarettes or more per day and those with 801-1,000 cigarette-years were 3.18 [1.18-8.53] and 3.44 [1.40-8.45], respectively, and positive linear associations were observed between that risk and the number of cigarettes per day (p for trend = 0.007) or "cigarette-years" (p for trend = 0.012). The alcohol dose was linearly associated with risk (p for trend = 0.004), where the HR among those who consumed 72.0 g or more of alcohol per day was 3.60 [1.29-9.85]. Among both men and women, cigarette smoking may elevate the risk of death from gallbladder cancer. Drinking may pose an elevated risk among men, but that seems to be less true among women. (c) 2007 Wilev-Liss. Inc.