Ion leakage is reduced during anoxia in turtle brain: a potential survival strategy.
Ion leakage is reduced during anoxia in turtle brain: a potential survival strategy.
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龟脑缺氧期间离子泄漏减少：一种潜在的生存策略。
DOI：
10.1152/ajpregu.1989.257.6.r1562
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sick,TJ
中科院分区：
文献类型：
--
作者：
Chih,CP;Rosenthal,M;Sick,TJ
龟脑维持ATP水平，离子稳态，和一些神经功能在长期缺氧，尽管ATP生产率显着下降。为了验证缺氧时ATP产生的减少部分是通过减少离子渗漏来保存能量来补偿的假设，在常氧和缺氧的龟脑中测量了K+渗漏率，其中Na（+）-K（+）-腺苷三磷酸酶被哇巴因抑制。缺氧2小时的脑K+渗漏率显著低于常氧脑。这些数据支持的建议，减少离子泄漏是一个重要的机制，在缺氧时的能量守恒。
The turtle brain maintains ATP levels, ion homeostasis, and some neural function during prolonged anoxia despite significant decreases in the rate of ATP production. To test the hypothesis that reduced ATP production during anoxia was compensated partly by conserving energy through reduced ion leakage, the rate of K+ leakage was measured in normoxic and anoxic turtle brains in which Na(+)-K(+)-adenosinetriphosphatase was inhibited with ouabain. Rates of K+ leakage were significantly lower in brains subjected to 2 h of anoxia than in normoxic brains. These data support the suggestion that reduced ion leakage is an important mechanism for energy conservation during anoxia.