Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women
Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women
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DOI：
10.1016/j.archger.2013.03.014
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发表时间：
2013-09-01
影响因子：
4
通讯作者：
Carvalho, Joana
中科院分区：
文献类型：
--
作者：
Marques, Elisa A.;Mota, Jorge;Carvalho, Joana
本研究探讨了32周的运动训练对老年人平衡、下肢肌肉力量、骨矿物质密度（BMD）、骨代谢和炎症标志物血清水平的影响。47名健康老年人（女性= 24，男性= 23;平均年龄68.2岁）参加了运动干预（60分钟/次），其中包括最大值的75-80%的阻力运动训练（2天/周）加上多组分负重冲击运动训练（1天/周）。结果指标包括腰椎和股骨近端BMD、动态平衡、肌力、血清骨代谢标志物[骨钙素（OC）、I型胶原C末端肽（CTX）、骨保护素（OPG）和核因子κ B配体受体激活剂（RANKL）]水平和血清炎症标志物[高敏（hs）-C反应蛋白（CRP）、白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ]。潜在的混杂变量包括身体成分、饮食摄入量（使用4天饮食记录）和基于加速计的体力活动。32周后，男性和女性的动态平衡（6.4%）、肌肉力量（11.0%）和转子（0.7%）、转子间（0.7%）、全髋（0.6%）和腰椎BMD（1.7%）均增加，而OC、CTX、OPG和RANKL水平保持不变。此外，hs-CRP和IFN-γ水平降低，而TNF-α水平不变，IL-6水平仅在男性中观察到降低。这些发现表明，我们的联合冲击方案减少了炎症，增加了BMD，平衡和下肢肌肉力量，尽管对骨代谢指标几乎没有影响。这加强了运动的作用，以抵消与年龄相关的炎症，以及肌肉力量，平衡和BMD降低。(c)2013爱思唯尔爱尔兰有限公司版权所有。
This study examines the effects of 32 weeks of exercise training on balance, lower-extremity muscle strength, bone mineral density (BMD) and serum levels of bone metabolism and inflammatory markers in older adults. Forty-seven healthy older adults (women = 24, men = 23; mean age 68.2 years) participated in a exercise intervention (60 min/session) that included resistance exercise training (2 days/week) at 75-80% of maximum plus a multicomponent weight-bearing impact exercise training (1 day/week). Outcome measures included lumbar spine and proximal femoral BMD, dynamic balance, muscle strength, serum levels of bone metabolism markers [osteocalcin (OC), C-terminal telopeptide of Type I collagen (CTX), osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL)] and serum levels of inflammatory markers [high sensitive (hs)-C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma]. Potential confounding variables included body composition, dietary intake (using 4-day diet records), and accelerometer-based physical activity. After 32 weeks, both men and women increased dynamic balance (6.4%), muscle strength (11.0%) and trochanter (0.7%), intertrochanter (0.7%), total hip (0.6%), and lumbar spine BMD (1.7%), while OC, CTX, OPG and RANKL levels remained unchanged. In addition, hs-CRP and IFN-gamma levels were decreased, while TNF-alpha levels were unchanged, and a decrease in IL-6 levels was only observed in men. These findings suggest that our combined impact protocol reduces inflammation and increases BMD, balance, and lower-extremity muscle strength, despite having little effect on bone metabolism markers. This reinforces the role of exercise to counteract the age-related inflammation, and the muscle strength, balance and BMD reduction. (c) 2013 Elsevier Ireland Ltd. All rights reserved.