Integration of the Reflex Pharyngeal Swallow Into Rhythmic Oral Activity in a Neurologically Intact Pig Model
Integration of the Reflex Pharyngeal Swallow Into Rhythmic Oral Activity in a Neurologically Intact Pig Model
复制标题
DOI：
10.1152/jn.00100.2009
复制
发表时间：
2009-08-01
影响因子：
2.5
通讯作者：
Thexton, Allan J.
中科院分区：
文献类型：
--
作者：
German, Rebecca Z.;Crompton, A. W.;Thexton, Allan J.
German RZ，Crompton AW，Thexton AJ.在神经系统完整的猪模型中，反射性咽吞咽与节律性口腔活动的整合。神经生理学杂志102：1017-1025，2009年。首次发表于2009年6月10日; doi：10.1152/jn.00100.2009。哺乳动物的吞咽涉及许多口咽肌肉的协调和顺序活动。采用同步肌电图（EMG）和视频荧光，我们记录了12个肌肉在吞咽神经系统完整的乳猪的EMG活动模式。我们检验了这一假设，即这种肌电图模式对应于已建立的活动模式，为孤立的，反射性咽部吞咽的去大脑幼猪。与正常吞咽的完整动物的肌电图活动有两个组成部分：一个交错的模式，单一的肌电图爆发，突出的茎突舌骨肌，甲状舌骨肌，环甲肌，肩胛舌骨肌和双爆发的活动在一些肌肉，包括颏舌骨肌和颏舌肌，具有相同的潜在的周期性吸吮。大多数交错的活动模式，在不同的肌肉中进行性延迟活动的线性序列，是没有统计学差异，从以前发现的反射性咽吞咽的去大脑动物。然而，并非反射性吞咽的线性序列的所有组件都被不变地插入到完整的吞咽中。有些成分似乎被延迟或提前，使它们与潜在的节律活动同步。吞咽的完整和去大脑动物之间的差异不仅仅是由于存在的节奏活动在前者。在完整的动物中的一些EMG活动的时间也不同于相同的活动，在少数去脑动物，表现出有节奏的舌头和下巴活动。这些结果表明，大脑功能影响咽吞咽的肌电图模式，这在传统上被认为是一个纯粹的反射模式。
German RZ, Crompton AW, Thexton AJ. Integration of the reflex pharyngeal swallow into rhythmic oral activity in a neurologically intact pig model. J Neurophysiol 102: 1017-1025, 2009. First published June 10, 2009; doi: 10.1152/jn.00100.2009. Mammalian swallowing involves the coordinated and sequential activity of many oropharyngeal muscles. Using synchronous electromyography (EMG) and videofluorography, we recorded the pattern of EMG activity for 12 muscles during swallowing in neurologically intact suckling pigs. We tested the hypothesis that this EMG pattern corresponded to the established pattern of activity for the isolated, reflexive pharyngeal swallow of the decerebrate infant pig. The EMG activity associated with the normal swallow of the intact animal had two components: a staggered pattern of single EMG bursts that were prominent in the stylohyoid, thyrohyoid, cricothyroid, and omohyoid muscles and double bursts of activity in some muscles, including geniohyoid and genioglossus, with the same underlying periodicity as suckling. Most of the staggered activity pattern, a linear sequence of progressively delayed activities in different muscles, was not statistically different from that previously found in the reflexive pharyngeal swallow of the decerebrate. However, not all components of the linear sequence of the reflexive swallow were inserted unchanged into the intact swallow. Some components appeared to be delayed or advanced, bringing them into phase with the underlying rhythmic activity. The difference between swallows of intact and of decerebrate animals was not solely due to the presence of rhythmic activity in the former. The timing of some EMG activities in intact animals also differed from the same activities in the few decerebrates that exhibited rhythmic tongue and jaw activity. These results suggest cerebral function influences the EMG pattern of the pharyngeal swallow, which has traditionally been considered a purely reflex pattern.