Expression of eosinophil-specific chemokines by human epithelial cells.
Expression of eosinophil-specific chemokines by human epithelial cells.
复制标题
人上皮细胞表达嗜酸性粒细胞特异性趋化因子。
DOI：
10.1159/000058785
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发表时间：
2000
影响因子：
--
通讯作者：
Beck,LA
中科院分区：
文献类型：
--
作者：
Stellato,C;Beck,LA
嗜酸性粒细胞在组织中的优先积累和/或嗜酸性粒细胞颗粒蛋白的沉积是几种炎症性人类疾病（如寄生虫感染和慢性过敏性疾病）的组织学标志之一。慢性过敏性哮喘是一种典型的嗜酸性粒细胞疾病，目前已经确定嗜酸性粒细胞及其产物，如细胞毒性颗粒蛋白和新合成的白三烯，参与气道黏膜的病理改变，如气道上皮的破坏、气道神经末梢的致敏和血管渗漏[1-4]。炎症组织中嗜酸性粒细胞和其他白细胞的选择性募集是一个复杂的、多步骤的过程，包括白细胞活化、边缘、与内皮细胞的牢固粘附和渗出。这一过程可能是由引起嗜酸性粒细胞启动和增加存活的细胞因子（IL-3、IL-5、GM-CSF）与激活内皮的细胞因子（IL-1、TNFa、IL-4、IL-13）以及嗜酸性粒细胞选择性趋化剂分子（尤其是趋化因子[6]）协同作用介导的。趋化因子是一个小的，结构相关的细胞因子家族，其中包括许多有效的嗜酸性粒细胞趋化剂，现在被认为是组织嗜酸性粒细胞的重要介质。虽然现在很明显趋化因子的活性范围比趋化更广泛——包括对各种细胞类型的血管生成、增殖和凋亡的影响，参与微生物发病——在稳态和炎症状态下调节白细胞运输被一致认为是趋化因子的基本功能[7,8]。白三烯B4、血小板活化因子、C5a和n -甲酰基肽等“经典”趋化剂在招募炎症方面显示出强大的、但非选择性的活性
The preferential accumulation of eosinophils and/or deposition of eosinophil granule proteins in the tissues is one of the histological hallmarks of several inflammatory human diseases such as parasitic infestations and chronic allergic diseases. In chronic allergic asthma, a prototypic eosinophilic disease, it is now well established that eosinophils and their products, such as cytotoxic granule proteins and de novo synthesized leukotrienes, are involved in pathological changes seen in the airway mucosa, such as destruction of airway epithelium, sensitization of airway nerve terminals and vascular leakage [1–4]. The selective recruitment of eosinophils and other leukocytes within inflamed tissues is a complex, multistep process that involves leukocyte activation, margination, firm adhesion to endothelium and diapedesis [5]. Such process is likely mediated by the cooperative action of cytokines which cause eosinophil priming and increased survival (IL-3, IL-5, GM-CSF) with those which activate endothelium (IL-1, TNFa, IL-4, IL-13) and with eosinophil-selective chemoattractant molecules, especially chemokines [6]. Chemokines are a family of small, structurally related cytokines which include numerous potent eosinophil chemoattractants that are now thought to be important mediators of tissue eosinophilia. Although it is now apparent that the spectrum of activities of chemokines is broader than chemotaxis–including effects on angiogenesis, proliferation and apoptosis of a variety of cell types, participation in microbial pathogenesis–the regulation of leukocyte traffiking in both homeostatic and inflammatory states is unanimously recognized as a fundamental function of chemokines [7, 8]. The ‘classical’chemoattractants such as leukotriene B4, platelet-activating factor, C5a and N-formyl peptides display potent, but nonselective activity in recruiting inflammatory