Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease
Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease
复制标题
DOI：
10.1016/s0042-6989(96)00066-1
复制
发表时间：
1997-12-01
期刊：
影响因子：
1.8
通讯作者：
Leigh, RJ
中科院分区：
文献类型：
--
作者：
Rottach, KG;Von Maydell, RG;Leigh, RJ
我们测量了三名患有Niemann-Pick型C型病的姐妹的眼球运动，她们有垂直扫视的选择性缺陷，这是缓慢和低计量的。水平扫视、水平和垂直追逐以及前庭眼运动与对照组相似。斜扫视的初始运动主要是水平运动，大部分垂直运动发生在水平运动结束后；这导致了强烈弯曲的轨迹。斜视扫视的水平部分完成后，眼睛以10-20 Rz的速度水平振荡，直到垂直部分结束。这些发现最好的解释是包含水平和垂直胸围神经元的单独反馈回路的模型，在这种模型中，疾病选择性地影响垂直胸围神经元。Elsevier Science Ltd.出版。
We measured the eye movements of three sisters with Niemann-Pick type C disease who had a selective defect of vertical saccades, which were slow and hypometric. Horizontal saccades, and horizontal and vertical pursuit and vestibular eye movements were similar to control subjects. The initial movement of oblique saccades was mainly horizontal and most of the vertical component occurred after the horizontal component ended; this resulted in strongly curved trajectories. After completion of the horizontal component of an oblique saccade, the eyes oscillated horizontally at 10-20 Rz until the vertical component ended, These findings are best explained by models that incorporate separate feedback loops for horizontal and vertical bust neurons, and in the which the disease selectively affects vertical burst neurons. Published by Elsevier Science Ltd.