Select: The next prostate cancer prevention trial
Select: The next prostate cancer prevention trial
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DOI：
10.1016/s0022-5347(05)65759-x
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发表时间：
2001-10-01
影响因子：
6.6
通讯作者：
Coltman, C
中科院分区：
文献类型：
--
作者：
Klein, EA;Thompson, IM;Coltman, C
目的：越来越多的证据表明硒和维生素E可以降低前列腺癌的风险。硒和维生素E的癌症预防试验（SELECT）是一项随机前瞻性双盲研究，旨在确定是否硒和维生素E降低前列腺癌的风险在health.Materials和方法：临床前和流行病学证据有关的化学预防硒和维生素E进行了审查。当前分析中纳入了2种药物随机试验的次要分析。从这些分析的数据，以及从前列腺癌预防试验的证据被用来开发的SELECT schema.Results：临床前，流行病学和III期的数据意味着，硒和维生素E有潜在的疗效前列腺癌的预防。前列腺癌预防试验的经验表明健康男性对癌症预防长期研究的兴趣和奉献精神。共有32，400名男性计划随机在SELECT.Conclusions：SELECT是第二个大规模的前列腺癌化学预防研究。计划于2001年开始招募研究人员，预计2013年获得最终结果。
Purpose: Growing evidence implies that selenium and vitamin E may decrease the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized prospective double-blind study designed to determine whether selenium and vitamin E decrease the risk of prostate cancer in healthy men.Materials and Methods: The preclinical and epidemiological evidence regarding chemoprevention with selenium and vitamin E were reviewed. Secondary analyses from randomized trials of the 2 agents were included in the current analysis. Data from these analyses as well as evidence from the Prostate Cancer Prevention Trial were used to develop the SELECT schema.Results: Preclinical, epidemiological and phase III data imply that selenium and vitamin E have potential efficacy for prostate cancer prevention. The experience of the Prostate Cancer Prevention Trial shows the interest and dedication of healthy men to long-term studies of cancer prevention. A total of 32,400 men are planned to be randomized in SELECT.Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment in the study is planned to begin in 2001 with final results anticipated in 2013.