The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury.
The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury.
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DOI：
10.1038/kisup.2014.6
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发表时间：
2014-11
影响因子：
5.5
通讯作者：
Duffield JS
中科院分区：
文献类型：
--
作者：
Gomez IG;Duffield JS
最近的研究发现肾脏中存在大量的血管周围间充质细胞，这些细胞来源于肾形成过程中的后肾间充质祖细胞，在此期间它们表达转录因子FOXD1。一些研究称其为常驻成纤维细胞，而另一些则称其为周细胞。无论如何命名，许多都部分整合到毛细血管基底膜中，并以重要的方式促进小管周围毛细血管的稳态。使用条件CreER重组酶介导的离散细胞队列追踪的命运定位研究已经确定这些周细胞和常驻成纤维细胞是肾脏疾病动物模型中间质肌成纤维细胞的主要前体群体。在这里，我们将回顾它们是肌成纤维细胞前体的主要群体的证据，强调在体内平衡中的一些关键功能，并关注细胞信号通路，这些信号通路对它们分化为肌成纤维细胞并持续存在很重要。
Recent studies have identified a poorly appreciated yet extensive population of perivascular mesenchymal cells in the kidney, which are derived from metanephric mesenchyme progenitor cells during nephrogenesis at which time they express the transcription factor FOXD1. Some studies have called these resident fibroblasts, whereas others have called them pericytes. Regardless of nomenclature, many are partially integrated into the capillary basement membrane and contribute in important ways to the homeostasis of peritubular capillaries. Fate-mapping studies using conditional CreER recombinase-mediated tracing of discrete cell cohorts have identified these pericytes and resident fibroblasts as the major precursor population of interstitial myofibroblasts in animal models of kidney disease. Here, we will review the evidence that they are the major population of myofibroblast precursors, highlight some critical functions in homeostasis, and focus on the cell signaling pathways that are important to their differentiation into, and persistence as myofibroblasts.