Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity
Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity
复制标题
DOI：
10.2807/1560-7917.es2014.19.23.20828
复制
发表时间：
2014-06-12
期刊：
影响因子：
19
通讯作者：
Peiris, M.
中科院分区：
文献类型：
--
作者：
Hemida, M. G.;Perera, R. A.;Peiris, M.
当用于动物血清流行病学研究时，假颗粒病毒中和试验（ppNT）和常规微量中和（MN）试验对检测中东呼吸综合征冠状病毒（MERS-CoV）抗体具有特异性。遗传多样性MERS-CoV在MN测试中出现抗原相似。我们确认MERS CoV于1993年在沙特阿拉伯的单峰骆驼中传播。初步数据表明，野生澳大利亚单峰骆驼可能没有MERS-CoV，但需要更大规模的验证性研究。
The pseudoparticle virus neutralisation test (ppNT) and a conventional microneutralisation (MN) assay are specific for detecting antibodies to Middle East respiratory syndrome coronavirus (MERS-CoV) when used in seroepidemiological studies in animals. Genetically diverse MERS-CoV appear antigenically similar in MN tests. We confirm that MERS-CoV was circulating in dromedaries in Saudi Arabia in 1993. Preliminary data suggest that feral Australian dromedaries may be free of MERS-CoV but larger confirmatory studies are needed.