Mitochondrial Macrohaplogroup Associated with Muscle Power in Healthy Adults
Mitochondrial Macrohaplogroup Associated with Muscle Power in Healthy Adults
复制标题
DOI：
10.1055/s-0031-1301317
复制
发表时间：
2012-05-01
影响因子：
2.5
通讯作者：
Miyachi, M.
中科院分区：
文献类型：
--
作者：
Fuku, N.;Murakami, H.;Miyachi, M.
本研究旨在研究线粒体单倍型对有氧和无氧性能表型的影响，如最大耗氧量，肌肉力量和肌肉质量。我们招募了474名健康的日本人，并测量了他们的身体表现表型，如峰值摄氧量，肌肉力量和肌肉质量。确定了线粒体DNA中186个多态性的基因型，并将单倍型分为2个宏单倍型组（即，N和M）和12个单倍群（即，F、B、A、N9 a、N9 B、M7 a、M7 B、G1、G2、D4 a、D4 B和D5）。当我们比较2个主要的日本宏单倍型群时，线粒体宏单倍型群N的受试者的腿部伸展能力（P = 0.0395）、基于体重的腿部伸展能力（P = 0.0343）和垂直跳跃能力（P = 0.0485）显著高于宏单倍型群M的受试者。然而，两组之间的峰值摄氧量相似。当我们分析12个单倍型群时，所有测量的参数在它们之间是相似的。因此，线粒体宏单倍群N可能是肌肉力量等无氧体能表型的决定因素之一。
The present study was undertaken to examine the effect of mitochondrial haplogroups on aerobic and anaerobic performance phenotypes such as maximum oxygen consumption, muscle power, and muscle mass. We recruited 474 healthy Japanese individuals and measured their physical performance phenotypes such as peak oxygen uptake, muscle power, and muscle mass. The genotypes for 186 polymorphisms in the mitochondrial DNA were determined, and the haplotypes were classified into 2 macrohaplogroups (i.e., N and M) and 12 haplogroups (i.e., F, B, A, N9a, N9b, M7a, M7b, G1, G2, D4a, D4b, and D5). When we compared the 2 major Japanese macrohaplogroups, leg extension power (P = 0.0395), leg extension power based on body weight (P = 0.0343), and vertical jump performance (P = 0.0485) were significantly higher in subjects with mitochondrial macrohaplogroup N than in those with macrohaplogroup M. However, peak oxygen uptake was similar between the 2 groups. When we analyzed the 12 haplogroups, all of the measured parameters were similar among them. In conclusion, mitochondrial macrohaplogroup N may be one of the determinant factors of anaerobic physical performance phenotype such as muscle power.