Impact of spatial resolution on the prediction of trabecular architecture parameters
Impact of spatial resolution on the prediction of trabecular architecture parameters
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DOI：
10.1016/s8756-3282(98)00031-3
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发表时间：
1998-05-01
期刊：
影响因子：
4.1
通讯作者：
Majumdar, S
中科院分区：
文献类型：
--
作者：
Kothari, M;Keaveny, TM;Majumdar, S
尽管各种评估小梁骨结构的措施的有效性已经被广泛研究，但空间分辨率对这些措施估计的影响仍然相对未被探索。在这项研究中，我们从9具年龄在23-67岁（平均42.3岁）的尸体（4男5女）中获得了10块来自股骨和椎体的人类小梁骨立方体，这些标本被连续磨碎，并以40 μ m的分辨率成像，以产生三维数字化，从而可以基于三维方法计算传统的形态测量和结构各向异性测量。然后，这些立方体被人为地降解为100 μ m的面内分辨率和100-1000 μ m的面外（切片）分辨率，这些分辨率模拟了使用磁共振（MR）成像所看到的体内分辨率。使用阈值分割算法对原始图像和退化图像进行分割，并重新计算传统的形态测量和结构各向异性测量。切片方向的选择沿着上下（轴向）、前后（冠状）和中外侧（矢状）方向变化，以尽量减少低切片分辨率对建筑测量的影响，发现传统的形态学测量如小梁间距和小梁数量对分辨率的依赖性较弱；然而，小梁厚度等测量显示出强烈的分辨率依赖性，并且需要非常高的分辨率才能进行精确测量。在股骨标本的情况下，结构各向异性和首选方向都显示出强烈的分辨率依赖性。如果沿上下方向进行切片，则股骨和椎体标本的这些参数的分辨率依赖性可以最小化。(C) 1998年Elsevier Science Inc .版权所有
Although the efficacy of various measures for the assessment of trabecular bone architecture has been widely studied, the impact of spatial resolution on the estimation of these measures has remained relatively unexplored. In this study, ten cubes each of human trabecular bone from the femur and vertebral bodies were obtained from nine cadavers (four males and five females), aged 23-67 years (mean 42.3 years), These specimens were serially milled and imaged at a resolution of 40 mu m to produce three-dimensional digitizations from which traditional morphometric and structural anisotropy measures could be computed based on a three-dimensional approach, The cubes were then artificially degraded to an in-plane resolution of 100 mu m and an out-of-plane (slice) resolution of 100-1000 mu m, These resolutions mimicked in vivo resolutions as seen using magnetic resonance (MR) imaging. All images, original and degraded, were individually segmented using a thresholding algorithm, and both the traditional morphometric and structural anisotropy measures were recomputed. The choice of slice direction was varied along the superior-inferior (axial), anterior-posterior (coronal), and medial-lateral (sagittal) directions to minimize the impact of the lower slice resolution on the architectural measures, It was found that traditional morphometric measures such as trabecular spacing and trabecular number showed weak resolution dependency; measures such as trabecular thickness, however, showed strong resolution dependency and required very high resolutions for precise measurement, In the case of the femur specimens, both structural anisotropy as well as the preferred orientation showed a strong resolution dependency. The resolution dependency of these parameters could be minimized for the femur and the vertebral body specimens if the slice direction was taken along the superior-inferior direction. (C) 1998 by Elsevier Science Inc, All rights reserved.