Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium.
Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium.
复制标题
甲状腺状态对心肌内在收缩特性和能量储存的影响。
DOI：
10.1172/jci105658
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发表时间：
1967
期刊：
影响因子：
--
通讯作者：
E. Braunwald
中科院分区：
文献类型：
--
作者：
R. Buccino;J. Spann;P. Pool;E. Sonnenblick;E. Braunwald
在三个水平的甲状腺活动和相关的血流动力学测量在完整的动物离体猫乳头肌和心肌高能磷酸盐商店的内在收缩特性进行了检查。此外，研究了甲状腺状态与内源性去甲肾上腺素储备和心肌对某些变力性干预的反应性的关系。在甲状腺功能亢进的猫的肌肉中，缩短的速度和张力发展的速度显着增加，而活动状态的持续时间减少，相比甲状腺功能正常的肌肉。这些发现发生在存在和不存在完整的去甲肾上腺素储存和广泛的温度和收缩频率。相反的变化发生在甲状腺功能减退的猫的肌肉。甲状腺功能亢进猫的肌肉等长张力略高，甲状腺功能减退猫的肌肉等长张力较低。对去甲肾上腺素和毒毛旋花子苷的变力反应与甲状腺状态的水平成反比，并且允许所有三组肌肉达到等长张力的共同上限，而不管甲状腺状态如何。磷酸肌酸和三磷酸腺苷储存在所有三个水平的甲状腺状态是完整的。因此，甲状腺活性水平深刻地影响心肌的内在收缩状态，独立于去甲肾上腺素储存和高能磷酸盐储存的改变，并且，此外，改变心肌对正性肌力药物的反应性。
The intrinsic contractile properties of isolated cat papillary muscles and myocardial high energy phosphate stores were examined at three levels of thyroid activity and correlated with hemodynamic measurements in the intact animal. In addition, the relationship of thyroid state to endogenous norepinephrine stores and myocardial responsiveness to certain inotropic interventions were studied. In muscles from hyperthyroid cats, the velocity of shortening and the rate of tension development were markedly augmented, while duration of active state was decreased, compared to euthyroid muscles. These findings occurred in the presence and absence of intact norepinephrine stores and over a wide range of temperature and contraction frequency. The opposite changes occurred in muscles from hypothyroid cats. Isometric tension was slightly higher in muscles from hyperthyroid and lower in muscles from hypothyroid cats. The inotropic response to both norepinephrine and strophanthidin varied inversely with the level of thyroid state and allowed all three groups of muscles to reach a common ceiling of isometric tension regardless of thyroid state. Creatine phosphate and adenosine triphosphate stores were intact at all three levels of thyroid state. Thus, the level of thyroid activity profoundly affects the intrinsic contractile state of cardiac muscle, independent of both norepinephrine stores and alterations in high energy phosphate stores, and, in addition, modifies the responsiveness of cardiac muscle to inotropic agents.