Topological turbulence in the membrane of a living cell
Topological turbulence in the membrane of a living cell
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DOI：
10.1038/s41567-020-0841-9
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发表时间：
2020-06
期刊：
影响因子：
19.6
通讯作者：
Tzer Han Tan;Jinghui Liu;Pearson W. Miller;Melis Tekant;J. Dunkel;N. Fakhri
中科院分区：
文献类型：
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作者：
Tzer Han Tan;Jinghui Liu;Pearson W. Miller;Melis Tekant;J. Dunkel;N. Fakhri
拓扑缺陷决定了物理和生物物质在广泛尺度上的结构和功能，从行星大气、海洋或量子流体中的湍流涡旋到心脏、大脑和细胞死亡中的生物电信号。在理解和控制主动、被动、非平衡流体的缺陷动力学方面已经取得了许多进展。然而，仍然未知控制经典或量子流体中缺陷动力学的统计定律是否扩展到生命系统中的活性物质和信息流。在这里，我们发现缺陷介导的湍流是海星卵细胞膜上 Rho-GTP 信号蛋白复杂波传播模式的基础，这一过程与细胞骨架重塑和细胞增殖相关。我们的实验表明，从 Rho-GTP 浓度波中提取的相速度场表现出涡旋缺陷运动和湮灭动力学，让人想起在量子系统、细菌湍流和活性向列中看到的那些。缺陷动力学的几个关键统计数据和标度定律可以通过最小的亥姆霍兹-昂萨格点涡模型以及通用的复杂金兹堡-朗道连续介质理论来捕获，这表明活细胞表面上的生化信号传播与广泛研究的二维湍流和波动现象之间存在密切的对应关系。
Topological defects determine the structure and function of physical and biological matter over a wide range of scales, from the turbulent vortices in planetary atmospheres, oceans or quantum fluids to bioelectrical signalling in the heart, –and brain, and cell death. Many advances have been made in understanding and controlling the defect dynamics in active, , –and passive,non-equilibrium fluids. Yet, it remains unknown whether the statistical laws that govern the dynamics of defects in classical or quantum fluids, –extend to the active matter,,and information flows,in living systems. Here, we show that a defect-mediated turbulence underlies the complex wave propagation patterns of Rho-GTP signalling protein on the membrane of starfish egg cells, a process relevant to cytoskeletal remodelling and cell proliferation,. Our experiments reveal that the phase velocity field extracted from Rho-GTP concentration waves exhibits vortical defect motions and annihilation dynamics reminiscent of those seen in quantum systems,, bacterial turbulence and active nematics. Several key statistics and scaling laws of the defect dynamics can be captured by a minimal Helmholtz–Onsager point vortex model as well as a generic complex Ginzburg–Landau continuum theory, suggesting a close correspondence between the biochemical signal propagation on the surface of a living cell and a widely studied class of two-dimensional turbulence and wave phenomena.