Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases.
Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases.
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DOI：
10.1007/978-94-007-7359-2_12
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发表时间：
2014
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中科院分区：
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碳酸酐酶IX(CAIX)是一种含锌的金属蛋白，能有效催化二氧化碳的可逆水合反应。它在几种癌症类型中呈结构性上调，并在肿瘤进展、酸化和转移中发挥重要作用。CAIX的高表达通常与预后不良相关，并与成功治疗后无病间隔的缩短有关。因此，它被认为是肿瘤学的预后指标。在这篇综述中，我们描述了CAIX的调节及其在肿瘤缺氧、酸化和转移中的作用。此外，还讨论了CAIX的分子成像及其在癌症检测、诊断、分期和后续治疗反应中的应用潜力。抗体和小分子化合物都被用于CAIX表达的靶向成像。文中还讨论了CAIX表达作为全身抗癌治疗有吸引力和前景的候选标记物的应用。
Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer types and has an important role in tumor progression, acidification and metastasis. High expression of CAIX generally correlates with poor prognosis and is related to a decrease in the disease-free interval following successful therapy. Therefore, it is considered as a prognostic indicator in oncology. In this review, we describe CAIX regulation and its role in tumor hypoxia, acidification and metastasis. In addition, the molecular imaging of CAIX and its potential for use in cancer detection, diagnosis, staging, and for use in following therapy response is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.