A Comparison of Clinical Trial Enrollment Between Adolescent and Young Adult (AYA) Oncology Patients Treated at Affiliated Adult and Pediatric Oncology Centers
A Comparison of Clinical Trial Enrollment Between Adolescent and Young Adult (AYA) Oncology Patients Treated at Affiliated Adult and Pediatric Oncology Centers
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DOI：
10.1097/mph.0b013e3181b91180
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发表时间：
2009-12-01
影响因子：
1.2
通讯作者：
Shaw, Peter H.
中科院分区：
文献类型：
--
作者：
Downs-Canner, Stephanie;Shaw, Peter H.
目的：在过去的30年里，与青少年和年轻成人（AYA）肿瘤患者相比，年轻儿科癌症患者的生存率急剧增加。这种差异的原因是多因素的，但很明显，临床试验招募与更好的outcomes.Patients和方法：我们研究了AYA肿瘤患者（年龄15至22岁）在附属儿科和成人癌症中心，匹兹堡儿童医院和匹兹堡大学癌症研究所治疗的临床试验的发病率。我们回顾性分析了所有新的癌症诊断和临床试验招募状态之间的2003年和2006年AYA患者在both institutions.Results：有91个新的AYA癌症诊断在匹兹堡儿童医院，其中24（26%）参加了临床试验。在同一时间段内，只有5 121新的AYA癌症患者（4%）在匹兹堡大学癌症研究所参加了临床试验，这是显着较低（P < 0.001）。结论：我们的数据表明，临床试验招募时，AYA患者在儿科癌症中心治疗是上级的。由于大多数AYA患者没有在儿科中心接受治疗，这可能部分解释了为什么他们的治愈率没有像年轻的儿科肿瘤患者那样显著提高。
Purpose: Over the past 30 years, there has been a dramatic increase in the survival rates of younger pediatric cancer patients in contrast to adolescent and young adult (AYA) oncology patients. The reasons for this discrepancy are multifactorial, but it is clear that clinical trial enrollment correlates with better outcomes.Patients and Methods: We examined the rate of clinical trial accrual of AYA oncology patients (aged 15 to 22 y) treated at affiliated pediatric and adult cancer centers, the Children's Hospital of Pittsburgh and the University of Pittsburgh Cancer Institute. We retrospectively analyzed all new cancer diagnoses and clinical trial enrollment status between 2003 and 2006 for AYA patients at both institutions.Results: There were 91 new AYA cancer diagnoses at Children's Hospital of Pittsburgh, of which 24 (26%) were enrolled on a clinical trial. During the same time period, only 5 of 121 new AYA cancer patients (4%) at University of Pittsburgh Cancer Institute were enrolled on a clinical trial, which was significantly lower (P < 0.001).Conclusions: Our data demonstrate that clinical trial enrollment was superior when AYA patients were treated at a pediatric cancer center. As most AYA patients are not treated at pediatric centers, this may partly explain why their cure rates have not improved as significantly as younger pediatric oncology patients.