Normalization of auditory physiology by cigarette smoking in schizophrenic patients.
Normalization of auditory physiology by cigarette smoking in schizophrenic patients.
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精神分裂症患者吸烟使听觉生理正常化。
DOI：
10.1176/ajp.150.12.1856
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Freedman,R
中科院分区：
文献类型：
--
作者：
Adler,LE;Hoffer,LD;Wiser,A;Freedman,R
由于许多精神分裂症患者是重度吸烟者，因此有人认为尼古丁可以使与疾病有关的一些神经元缺陷正常化。精神分裂症患者在保持注意力和选择性处理感觉信息方面存在各种困难。精神分裂症的感觉门控缺陷之一是记录听觉诱发电位。大多数正常受试者对两个紧密配对刺激中的第二个的诱发反应降低，而大多数精神分裂症受试者没有。本研究的目的是确定吸烟是否正常化这一赤字在听觉感觉门控在schizophrenia.Methodchanges在响应吸烟cigarettes的听觉感觉门控进行了研究，在10个吸烟者没有精神疾病和10个精神分裂症吸烟者。两组被要求从晚上11：00到第二天早上8：00戒烟，记录他们对成对点击的听觉诱发反应。门控感觉信息的能力反映在响应于两个刺激中的第二个的P50波幅的降低中。基线录音后，受试者吸烟，因为他们希望，然后两个postsmoking recordings.ResultsThe精神分裂症患者有一个显着的，但短暂的改善P50听觉门控吸烟后立即，而正常吸烟者的P50门控轻微imported.ConclusionsThis研究表明，吸烟可以短暂正常化精神分裂症患者的听觉感觉门控的损害。
ObjectiveBecause many schizophrenic patients are heavy smokers, it has been suggested that nicotine normalizes some neuronal deficit involved in their illness. Schizophrenic subjects have various difficulties with maintenance of attention and selective processing of sensory information. One defect in sensory gating in schizophrenia has been characterized by recording auditory evoked potentials. Most normal subjects have a decrease in the evoked response to the second of two closely paired stimuli, whereas most schizophrenic subjects do not. The aim of this study was to determine whether smoking normalizes this deficit in auditory sensory gating in schizophrenia.MethodChanges in auditory sensory gating in response to smoking cigarettes were studied in 10 smokers without psychiatric illness and 10 schizophrenic smokers. Both groups were asked to abstain from smoking from 11: 00 pm until 8: 00 am the next morning, when their auditory evoked responses to pairs of clicks were recorded. The ability to gate sensory information is reflected in a decrease in the P50 wave amplitude in response to the second of the two stimuli. After baseline recordings, the subjects smoked as much as they wished, and then two postsmoking recordings were performed.ResultsThe schizophrenic patients had a marked but brief improvement in P50 auditory gating immediately after smoking, whereas P50 gating for the normal smokers was slightly impaired.ConclusionsThis study suggests that cigarette smoking can transiently normalize the impairment of auditory sensory gating in schizophrenic patients.