EPITHELIAL‐MESODERMAL INTERACTION IN NORMAL HAIR GROWTH, ALOPECIA, AND NEOPLASIA
EPITHELIAL‐MESODERMAL INTERACTION IN NORMAL HAIR GROWTH, ALOPECIA, AND NEOPLASIA
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正常毛发生长、脱发和肿瘤中的上皮-中胚层相互作用
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发表时间：
1978
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通讯作者：
H. Pinkus
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作者：
H. Pinkus
近年来，人们对细胞和组织之间的相互作用以及受周围组织影响的细胞行为的控制已经有了很多了解。皮拉尔装置提供了组织相互作用的突出例子，如果我们能够理解支配毛发发育和生长的规律，我们将更接近于理解支配生命本身的规律（1），我将把我的讨论分为三个部分：正常的毛发生长;脱发，特别是所谓的瘢痕性脱发;和肿瘤，特别是基底细胞上皮瘤。正常“毛发器官从一开始就是纤维上皮器官（2）。胎儿上皮毛胚由间充质细胞的聚集支持和包围，并由PAS阳性基底膜与间充质细胞结合。初生中胚层胚芽是纤维根鞘的前体，在上皮柱向下生长通过真皮进入皮下脂肪组织期间，纤维根鞘包围并引导上皮柱。最后，它在中空的基质内形成真皮乳头，这个乳头是所有后来事件的总督。在生长期，皮拉尔基质细胞在形态上看起来完全相似，但它们以六种不同的方式成熟和角化
Much has been learned in recent years about cell and tissue interactions in general and about control of cell behavior by influences from surrounding tissues. The pilar apparatus offers outstanding examples of tissue interactions, and if we could understand the laws that govern development and growth of hair we would be much closer to understanding the laws that govern life itself (1), I'll divide my discussion into three parts: normal hair growth; alopecia, especially so-called scarring alopecia; and 'neoplasia, especially basal cell epithelioma. Normal' The hair apparatus is a fibro-epithelial organ from the beginning (2). The fetal epithelial hair germ IS supported and surrounded by an accumulation of mesenchymal cells, with which it is united by a PAS positive basement membrane. The primary mesodermal germ is the precursor of the fibrous root sheath which surrounds and guides the epithelial column during its downgrowth through the dermis into the subcutaneous fat tissue. Eventually it forms the dermal papilla inside the hollow matrix, and this papilla is the governor of all later events. During anagen, the pilar matrix cells appear to be completely alike morphologically, yet they mature and keratinize in six different ways to form