NON-SMOKING WIVES OF HEAVY SMOKERS HAVE A HIGHER RISK OF LUNG-CANCER - A STUDY FROM JAPAN
NON-SMOKING WIVES OF HEAVY SMOKERS HAVE A HIGHER RISK OF LUNG-CANCER - A STUDY FROM JAPAN
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DOI：
10.1136/bmj.282.6259.183
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发表时间：
1981-01-01
影响因子：
105.7
通讯作者：
HIRAYAMA, T
中科院分区：
文献类型：
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作者：
HIRAYAMA, T
在日本29个卫生中心区的一项研究中，对91540名年龄在40岁及以上的不吸烟妻子进行了长达14年的跟踪调查(1966-1979)，并根据丈夫的吸烟习惯评估了肺癌的标准化死亡率。重度吸烟者的妻子患肺癌的风险更高，且存在剂量-反应关系。根据丈夫的年龄和职业分析，丈夫S吸烟与妻子S患肺癌的风险呈现类似的模式。当丈夫在注册时年龄在40-59岁时，这种风险在农业家庭中尤其大。丈夫的吸烟习惯并不影响妻子死于胃癌、宫颈癌和缺血性心脏病等其他疾病的风险。重度吸烟者的不吸烟妻子患肺气肿和哮喘的风险似乎更高，但这种影响在统计学上并不显着。丈夫S的饮酒习惯似乎对他们妻子的任何死因都没有影响，包括肺癌。这些结果让人对通过比较吸烟者和不吸烟者来评估他们患肺癌的相对风险的做法产生了怀疑。
In a study in 29 health center districts in Japan, 91,540 nonsmoking wives aged 40 and above were followed up for 14 yr (1966-1979), and standardized mortality rates for lung cancer were assessed according to the smoking habits of their husbands. Wives of heavy smokers had a higher risk of developing lung cancer and a dose-response relation was observed. The relation between the husband''s smoking and the wife''s risk of developing lung cancer showed a similar pattern when analyzed by age and occupation of the husband. The risk was particularly great in agricultural families when the husbands were aged 40-59 at enrollment. The husbands'' smoking habit did not affect their wives'' risk of dying from other disease such as stomach cancer, cervical cancer and ischemic heart disease. The risk of developing emphysema and asthma seemed to be higher in nonsmoking wives of heavy smokers but the effect was not statistically significant. The husband''s drinking habit seemed to have no effect on any causes of death in their wives, including lung cancer. These results cast doubt on the practice of assessing the relative risk of developing lung cancer in smokers by comparing them with nonsmokers.